Severinsen Stig Avall, Sørensen Mads Sølvsten, Kirkegaard Mette, Nyengaard Jens R
Stereology and Electron Microscopy Research Laboratory and MIND Center, Aarhus University, Aarhus, Denmark.
Acta Otolaryngol. 2010 Jul;130(7):773-9. doi: 10.3109/00016480903397694.
Abstract Conclusion: There is no change in the total cell population and hair cell:supporting cell ratio in the human utricular macula from gestational week 16 and onwards, whereas the lower hair cell:supporting cell ratio and lower total number of cells in the youngest specimens indicate that the utricle is still differentiating and adding new cells at the 10th to 12th gestational week.
Archival temporal bones were investigated to quantify cell numbers in the utricular macula in fetuses and children.
The age of the subjects ranged from gestational week 10 to 15 years. The optical fractionator was used to estimate the total number of cells in the utricular macula.
The total cell number was found to be 143 000 in subjects older than gestational week 16. The number of hair cells and supporting cells did not change between the 16th gestational week and 15 years and was 36 000 and 107 000, respectively. In the youngest specimen (10th and 12th gestational week) there was a statistically significant lower total number of cells (62 000) and a lower hair cell:supporting cell ratio, resulting in a mean number of 13 000 hair cells and 49 000 supporting cells.
摘要 结论：从妊娠第16周及以后，人类椭圆囊斑的细胞总数以及毛细胞与支持细胞的比例没有变化，而最年轻标本中较低的毛细胞与支持细胞比例和较少的细胞总数表明，椭圆囊在妊娠第10至12周仍在分化并添加新细胞。
研究存档颞骨，以量化胎儿和儿童椭圆囊斑中的细胞数量。
受试者年龄范围为妊娠第10周到15岁。使用光学分割器估计椭圆囊斑中的细胞总数。
发现妊娠第16周以上的受试者细胞总数为143000。在妊娠第16周和15岁之间，毛细胞和支持细胞的数量没有变化，分别为36000和107000。在最年轻的标本（妊娠第10周和12周）中，细胞总数（62000）在统计学上显著较低，毛细胞与支持细胞的比例也较低，导致平均有13000个毛细胞和49000个支持细胞。
