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帕金森病的非运动症状:抑郁和痴呆。

Non-motor features of Parkinson's disease: depression and dementia.

机构信息

Department of Neurology, Dresden University of Technology, Germany.

出版信息

Parkinsonism Relat Disord. 2009 Dec;15 Suppl 3:S87-92. doi: 10.1016/S1353-8020(09)70789-8.

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disease and primarily considered as a movement disorder defined by the presence of motor symptoms, such as bradykinesia, tremor and rigidity. However, it is nowadays widely recognized that in addition there is impairment of cognitive function, mood and the autonomic nervous system in a high percentage of PD patients, which is sometimes even more harming quality of life. These symptoms not only occur during the course of the disease but may even precede the onset of motor symptoms. Typical examples of non-motor features of PD are depression, constipation, REM sleep behaviour disorder, and hyposmia.

摘要

帕金森病(PD)是第二常见的神经退行性疾病,主要被认为是一种运动障碍,其特征是存在运动症状,如运动迟缓、震颤和僵硬。然而,如今人们广泛认识到,除了运动症状外,相当一部分 PD 患者还存在认知功能、情绪和自主神经系统的损害,这有时甚至更会损害生活质量。这些症状不仅在疾病过程中出现,甚至可能在运动症状出现之前就已经出现。PD 的非运动特征的典型例子包括抑郁、便秘、快速眼动睡眠行为障碍和嗅觉减退。

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