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Calcium sensitivity, force frequency relationship and cardiac troponin I: critical role of PKA and PKC phosphorylation sites.
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Protein kinase C and A sites on troponin I regulate myofilament Ca2+ sensitivity and ATPase activity in the mouse myocardium.
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Cardiac Myosin-binding Protein C and Troponin-I Phosphorylation Independently Modulate Myofilament Length-dependent Activation.
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Protein kinase C depresses cardiac myocyte power output and attenuates myofilament responses induced by protein kinase A.
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Troponin I in the murine myocardium: influence on length-dependent activation and interfilament spacing.
J Physiol. 2003 Mar 15;547(Pt 3):951-61. doi: 10.1113/jphysiol.2002.038117. Epub 2003 Jan 24.

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Screening of key genes related to M6A methylation in patients with heart failure.
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Arg92Leu-cTnT Alters the cTnC-cTnI Interface Disrupting PKA-Mediated Relaxation.
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The lack of Troponin I Ser-23/24 phosphorylation is detrimental to in vivo cardiac function and exacerbates cardiac disease.
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Role of RONS and eIFs in Cancer Progression.
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2
Left ventricular and myocardial function in mice expressing constitutively pseudophosphorylated cardiac troponin I.
Circ Res. 2009 Dec 4;105(12):1232-9. doi: 10.1161/CIRCRESAHA.109.205427. Epub 2009 Oct 22.
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Negative charges at protein kinase C sites of troponin I stabilize the inactive state of actin.
Biophys J. 2008 Jan 15;94(2):542-9. doi: 10.1529/biophysj.107.113944. Epub 2007 Sep 14.
7
Frequency-dependent myofilament Ca2+ desensitization in failing rat myocardium.
J Physiol. 2007 Jul 15;582(Pt 2):695-709. doi: 10.1113/jphysiol.2007.134486. Epub 2007 May 3.
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Nitroxyl increases force development in rat cardiac muscle.
J Physiol. 2007 May 1;580(Pt.3):951-60. doi: 10.1113/jphysiol.2007.129254. Epub 2007 Mar 1.
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Frequency-dependent acceleration of relaxation involves decreased myofilament calcium sensitivity.
Am J Physiol Heart Circ Physiol. 2007 May;292(5):H2212-9. doi: 10.1152/ajpheart.00778.2006. Epub 2007 Jan 5.
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PKC-betaII sensitizes cardiac myofilaments to Ca2+ by phosphorylating troponin I on threonine-144.
J Mol Cell Cardiol. 2006 Nov;41(5):823-33. doi: 10.1016/j.yjmcc.2006.08.016. Epub 2006 Sep 29.

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