Department of Hygiene and Epidemiology, University of Porto Medical School, Alameda Professor Hernâni Monteiro 4200-319, Porto, Portugal.
Alcohol Alcohol. 2010 Mar-Apr;45(2):119-25. doi: 10.1093/alcalc/agp092. Epub 2010 Jan 18.
To assess the association of alcohol intake with high-sensitivity C-reactive protein (hs-CRP), uric acid and leukocyte count in blood, and whether sex and body mass index (BMI) modify these associations.
Individuals aged > or =18 years were randomly selected from the population of Porto, Portugal (70% of participation). A total of 840 women and 490 men with reliable information on inflammatory markers and alcohol intake, obtained from a validated food frequency questionnaire, were studied. Associations and their respective trends were estimated from generalized linear models, with adjustment for potential confounders. Analyses were stratified by sex and BMI.
In women, adjusted hs-CRP levels (mg/l) were 2.69 in non-drinkers, 2.25 in drinkers of >0-15 g alcohol/day, 2.32 in drinkers of >15-30 g alcohol/day and 3.18 in drinkers of >30 g alcohol/day (P-value for the quadratic trend <0.001). In men, the association between alcohol intake and hs-CRP was positive and linear (P-value for the linear trend = 0.014). Alcohol intake was also positively and linearly associated with uric acid in each sex. Body weight modified these associations, which remained statistically significant only in normal-weight (BMI <25 kg/m(2)) women and overweight (BMI > or =25 kg/m(2)) men for hs-CRP, and in normal-weight individuals for uric acid. No significant association between alcohol intake and leukocyte count was found.
The association of alcohol intake with hs-CRP was J-shaped in women but positive and linear-shaped in men. Alcohol intake was directly associated with uric acid in men and women. BMI modifies the effect of alcohol on hs-CRP and uric acid levels in each sex.
评估饮酒与高敏 C 反应蛋白（hs-CRP）、血尿酸和白细胞计数之间的关系，以及性别和体重指数（BMI）是否会改变这些关系。
从葡萄牙波尔图的人群中随机选择年龄≥18 岁的个体（参与率为 70%）。共研究了 840 名女性和 490 名男性，他们有可靠的炎症标志物和饮酒量信息，这些信息来自经过验证的食物频率问卷。使用广义线性模型估计关联及其各自的趋势，并进行潜在混杂因素的调整。按性别和 BMI 进行分层分析。
在女性中，调整后的 hs-CRP 水平（mg/L）分别为不饮酒者 2.69、饮酒 0-15 g/天者 2.25、饮酒 15-30 g/天者 2.32 和饮酒>30 g/天者 3.18（二次趋势 P 值<0.001）。在男性中，饮酒与 hs-CRP 之间的关系呈正相关且线性（线性趋势 P 值=0.014）。在两性中，饮酒与血尿酸之间也呈正相关且线性关系。体重改变了这些关联，仅在正常体重（BMI<25 kg/m2）女性和超重（BMI≥25 kg/m2）男性中，hs-CRP 以及在正常体重个体中，血尿酸的关联仍具有统计学意义。饮酒与白细胞计数之间无显著相关性。
女性饮酒与 hs-CRP 之间的关系呈 J 形，而男性呈正相关且线性关系。饮酒与男性和女性的血尿酸直接相关。BMI 改变了酒精对两性中 hs-CRP 和血尿酸水平的影响。
