双硫仑，治疗病理性赌博的一种选择？
Disulfiram, an option for the treatment of pathological gambling?
机构信息
Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Square J 5 68159 Mannheim, Germany.
出版信息
Alcohol Alcohol. 2010 Mar-Apr;45(2):214-6. doi: 10.1093/alcalc/agp093. Epub 2010 Jan 18.
AIM
Pathological gambling and comorbid alcohol dependence often occur in combination. Disulfiram is one of the proven drugs for alcohol dependence. In addition to its inhibiting acetaldehyde dehydrogenase, disulfiram inhibits dopamine beta-hydroxylase and may thereby increase dopamine and decrease norepinephrine cerebral concentrations. Because there may be common neurochemical substrates and neuronal circuits for pathological gambling and addiction, we wished to explore the effect of disulfiram in gambling.
METHOD
We describe the outcome of a patient with alcohol dependence and pathological gambling treated with disulfiram D.
RESULTS
During treatment with disulfiram, the patient reported that his desire to gamble disappeared entirely. Follow-up indicated that he has not gambled for >12 months.
CONCLUSIONS
Although uncontrolled case observations should be interpreted with caution, disulfiram deserves further investigation in pathological gambling.
目的
病理性赌博和并发酒精依赖经常同时出现。双硫仑是一种已被证实可用于治疗酒精依赖的药物。除了抑制乙醛脱氢酶，双硫仑还抑制多巴胺β-羟化酶，从而可能增加多巴胺并减少去甲肾上腺素的脑浓度。因为病理性赌博和成瘾可能存在共同的神经化学基础和神经元回路，我们希望探索双硫仑对赌博的影响。
方法
我们描述了一名酒精依赖和病理性赌博患者使用双硫仑 D 的治疗结果。
结果
在使用双硫仑治疗期间，患者报告说他完全失去了赌博的欲望。随访表明，他已经超过 12 个月没有赌博了。
结论
尽管无对照的病例观察应谨慎解释，但双硫仑值得进一步研究病理性赌博。
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