双硫仑治疗严重酒精中毒——一项开放性对照研究。
Disulfiram in severe alcoholism--an open controlled study.
作者信息
Ulrichsen Jakob, Nielsen Mogens Kai, Ulrichsen Michelle
机构信息
Psychiatric Center Gentofte, Copenhagen University Hospitals, Denmark.
出版信息
Nord J Psychiatry. 2010 Dec;64(6):356-62. doi: 10.3109/08039481003686180. Epub 2010 Mar 18.
BACKGROUND
Disulfiram is used to a great extent in Denmark to treat alcoholism but the evidence is limited.
AIM
To study the effect of supervised disulfiram treatment in alcohol dependence. Subjects were recruited from a psychiatric emergency ward following alcohol withdrawal treatment.
METHODS
A total of n=39 patients were openly randomized to either disulfiram 800 mg twice a week for 26 weeks (n=19) or no disulfiram (n=20). All patients were also treated with cognitive behavioural therapy (CBT) in groups.
RESULTS
The rate of abstinence was 20% and 26% in the control and disulfiram group, respectively. This difference was not statistically significant (NS). A trend towards increased mean time to first drink was found in the disulfiram group (96 vs. 76 days in the control group, NS), while fewer patients in this group completed CBT group therapy (41% vs. 67% in the control group, NS). Alcohol-free days were 100 days in both groups (NS).
CONCLUSION
Supervised disulfiram administration did not have any major impact on the treatment outcome.
背景
在丹麦，双硫仑被广泛用于治疗酒精成瘾，但证据有限。
目的
研究在监督下使用双硫仑治疗酒精依赖的效果。研究对象从接受酒精戒断治疗后的精神科急诊病房招募。
方法
总共n = 39例患者被公开随机分为两组，一组每周两次服用800毫克双硫仑，共26周（n = 19），另一组不服用双硫仑（n = 20）。所有患者还接受了团体认知行为疗法（CBT）。
结果
对照组和双硫仑组的戒酒率分别为20%和26%。这种差异无统计学意义（NS）。双硫仑组首次饮酒的平均时间有增加的趋势（对照组为96天，双硫仑组为76天，无统计学意义），而该组完成CBT团体治疗的患者较少（对照组为67%，双硫仑组为41%，无统计学意义）。两组的戒酒天数均为100天（无统计学意义）。
结论
在监督下服用双硫仑对治疗结果没有任何重大影响。
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