Lindsay Robin W, Heaton James T, Edwards Colin, Smitson Christopher, Hadlock Tessa A
Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston, USA.
Arch Facial Plast Surg. 2010 Jan-Feb;12(1):49-52. doi: 10.1001/archfacial.2009.95.
To establish whether nimodipine, a calcium channel blocker, accelerates or otherwise improves functional recovery of whisking after facial nerve crush injury in the rat.
Thirty rats underwent exposure of the left main trunk of the facial nerve followed by a standard crush injury and subsequent quantitative facial movement testing. Animals were randomized into an experimental group (n = 15) and a control group (n = 15). Four days prior to facial nerve manipulation, experimental animals underwent subcutaneous implantation of a nimodipine-secreting pellet. All animals were tested preoperatively and on postoperative days 2, 8 to 17, 20, 22, 24, and 31 using a validated, quantitative whisking kinematics apparatus. Whisks were analyzed for amplitude, velocity, and acceleration.
Animals receiving nimodipine demonstrated significantly better whisking on 5 days (postoperative days 9, 11 to 13, and 20) compared with control animals (P < .001, P = .003, P = .009, P = .009, and P = .009, respectively; 1-tailed ttest). Overall, the nimodipine-treated animals showed earlier recovery compared with the untreated animals.
We demonstrate that nimodipine improves recovery of whisking after facial nerve crush. This finding corroborates the semiquantitative findings of others, and provides complete whisking kinematic data on its effects. Given the low adverse effect profile of nimodipine, there may be clinical implications in its administration in patients experiencing facial nerve injury.
确定钙通道阻滞剂尼莫地平是否能加速或改善大鼠面神经挤压伤后触须功能的恢复。
30只大鼠接受左侧面神经主干暴露，随后进行标准挤压伤及后续定量面部运动测试。动物被随机分为实验组（n = 15）和对照组（n = 15）。在面神经操作前4天，对实验组动物进行皮下植入分泌尼莫地平的微丸。所有动物在术前以及术后第2天、第8至17天、第20天、第22天、第24天和第31天，使用经过验证的定量触须运动学装置进行测试。分析触须的幅度、速度和加速度。
与对照组动物相比，接受尼莫地平治疗的动物在5天（术后第9天、第11至13天和第20天）的触须表现明显更好（分别为P <.001、P =.003、P =.009、P =.009和P =.009；单尾t检验）。总体而言，与未治疗的动物相比，接受尼莫地平治疗的动物恢复更早。
我们证明尼莫地平可改善面神经挤压伤后触须的恢复。这一发现证实了其他人的半定量研究结果，并提供了关于其作用的完整触须运动学数据。鉴于尼莫地平的不良反应较少，其在面神经损伤患者中的应用可能具有临床意义。
