Chełkowski's Institute of Physics, Department of Medical Physics, University of Silesia, 40 007 Katowice, ul. Uniwersytecka 4, Poland.
J Fluoresc. 2011 May;21(3):883-6. doi: 10.1007/s10895-009-0591-7. Epub 2010 Jan 19.
The influence of antiretroviral drug zidovudine treatment during pregnancy on mandible development in newborn rats was studied. The fluorescence of mandibles from 7-, 14- and 28-days old individuals was measured by means of fiber-optical fluorescence analyzer with 407 nm laser excitation. Obtained results revealed disturbing effect of maternal zidovudine administration on mandible fluorescence intensity which should decrease with bone development. Small changes in fluorescence of porphyrin forms are maintaining in the first month of newborns life while the changes observed in 440-585 nm range disappear.
研究了妊娠期间抗逆转录病毒药物齐多夫定治疗对新生大鼠下颌骨发育的影响。使用 407nm 激光激发的光纤荧光分析仪测量了 7、14 和 28 天大的个体下颌骨的荧光强度。结果表明，母体齐多夫定给药对下颌骨荧光强度有干扰作用，而荧光强度应随骨骼发育而降低。在新生儿生命的第一个月，卟啉形式的荧光强度变化很小，而在 440-585nm 范围内观察到的变化则消失。
