Ersek R A, Stovall R B, Vazquez-Salisbury A
Southwest Texas State University, Austin, USA.
Plast Reconstr Surg. 1995 May;95(6):985-92. doi: 10.1097/00006534-199505000-00005.
The plethora of problematic techniques for improving minor chin recessions has left the plastic surgeon inevitably uncertain of the most effective remedy. Research we began in 1968 has led us to the development of a new biphasic polymer and minimally invasive implantation techniques aimed at solving the soft-tissue deficiency dilemma. Bioplastique consists of inert, textured particles of critical dimension dispersed within a bioexcretable gel vehicle. Previous experimentation in rabbit ears has shown that the gel component is rapidly phagocytosed, excreted, and replaced by a fibrin matrix within 3 days. The matrix is then replaced by host collagen, gradually forming a stable encasement around each microparticle. Further evaluation has revealed that the implant resists migration and absorption. Based on these encouraging results, a clinical phase was initiated. Thirteen patients lacking chin prominence have subsequently been improved with Bioplastique implants. The infection rate was 0 percent, and other complications were minor. At 26 months, no evidence of migration or absorption has been observed, and the aesthetic results remain.
改善轻度下巴后缩的问题技术众多,这使得整形外科医生不可避免地对最有效的治疗方法感到不确定。我们于1968年开始的研究促使我们开发出一种新型双相聚合物和微创植入技术,旨在解决软组织缺陷难题。Bioplastique由分散在可生物排泄凝胶载体中的具有临界尺寸的惰性、有纹理颗粒组成。先前在兔耳上进行的实验表明,凝胶成分在3天内会迅速被吞噬、排泄,并被纤维蛋白基质取代。然后,基质被宿主胶原蛋白取代,逐渐在每个微粒周围形成稳定的包裹。进一步评估显示,植入物能抵抗迁移和吸收。基于这些令人鼓舞的结果,启动了临床阶段。随后,13名下巴不突出的患者通过Bioplastique植入得到了改善。感染率为0%,其他并发症也很轻微。在26个月时,未观察到迁移或吸收的迹象,美学效果依然存在。