Ozdemir Rahim, Er Hakan, Baran Nurten, Vural Ahmet, Demirci Mustafa
Mikrobiyol Bul. 2009 Oct;43(4):709-11.
In this study, the seropositivity rates of herpes simplex virus (HSV) types 1 and 2, and their distribution according to the age groups in the sera of asymptomatic pregnant women who were admitted to Gynecology and Obstetrics clinics of Izmir Ataturk Research and Training Hospital for routine control, were investigated. IgG and IgM antibodies specific for HSV-1 and HSV-2 were screened by commercial ELISA kits (RADIM SpA-Pomezia, Italia). Total IgG seropositivity rates for HSV-1 and HSV-2 were found as 94.7% (108/114) and 8.2% (13/158), while IgM seropositivities were 0 (0/114) and 1.4% (2/148), respectively. The distribution of HSV-1 and HSV-2 IgG seropositivity rates according to the age groups were as follows; 100% (8/8) and 10% (1/10) in 18-20; 92.9% (26/28) and 13.9% (5/36) in 21-25; 93.3% (42/45) and 3% (2/66) in 26-30; 96.6% (28/29) and 8.3% (3/36) in 31-35 and 100% (4/4) and 20% (2/10) in 36-40 years age groups, respectively. HSV-2 IgM antibodies were positive only in 21-25 years age group (2/35; 5.7%). The difference between seropositivity rates of HSV-1 IgG and HSV-2 IgG were found statistically significant (p = 0.000, p < 0.05); whereas the differences between both HSV-1 IgG and IgM and HSV-2 IgG and IgM seropositivity rates in the age groups didn't display statistical significance (p = 0.872, p> 0.05; p = 0.217, p> 0.05). The aim of this letter was to contribute to the seroepidemiological data of HSV prevalance in pregnant women in our region.
在本研究中,对入住伊兹密尔阿塔图尔克研究与培训医院妇产科诊所进行常规检查的无症状孕妇血清中1型和2型单纯疱疹病毒(HSV)的血清阳性率及其按年龄组的分布情况进行了调查。采用商用ELISA试剂盒(意大利拉迪姆股份公司-波梅齐亚)筛查针对HSV-1和HSV-2的IgG和IgM抗体。HSV-1和HSV-2的总IgG血清阳性率分别为94.7%(108/114)和8.2%(13/158),而IgM血清阳性率分别为0(0/114)和1.4%(2/148)。HSV-1和HSV-2 IgG血清阳性率按年龄组的分布如下:18 - 20岁组为100%(8/8)和10%(1/10);21 - 25岁组为92.9%(26/28)和13.9%(5/36);26 - 30岁组为93.3%(42/45)和3%(2/66);31 - 35岁组为96.6%(28/29)和8.3%(3/36);36 - 40岁组分别为100%(4/4)和20%(2/10)。HSV-2 IgM抗体仅在21 - 25岁年龄组呈阳性(2/35;5.7%)。发现HSV-1 IgG和HSV-2 IgG血清阳性率之间的差异具有统计学意义(p = 0.000,p < 0.05);而各年龄组中HSV-1 IgG与IgM以及HSV-2 IgG与IgM血清阳性率之间的差异均无统计学意义(p = 0.872,p > 0.05;p = 0.217,p > 0.05)。这封信的目的是为我们地区孕妇HSV流行的血清流行病学数据提供补充。