Savchenko N Ia
Radiobiologiia. 1991 Jan-Feb;31(1):120-5.
The major regularities that govern the alteration of the higher nervous activities after irradiation with heavy charged particles have been grounded quantitatively. The influence of the environmental factors on the exposed organism acquires a stress nature and is accompanied by the alteration of the central-central and central-peripheric relationships in major nervous processes whose pathogenesis is determined, to some extent, by a change in the homeostatic level of the synaptic energy transfer rate that depends quantitatively on the response of the irradiated organism at different stages of the development of radiation damage. The rate of the synaptic transfer at early periods of radiation damage development is 11.6, 9.7, and 12.4 (relative units) corresponding to the stages of radiation affection by heavy charged particles which permits to compare qualitatively and quantitatively the reactions of final acceptors of various executive morphofunctional structures after irradiation with heavy charged particles.
定量地确定了重带电粒子辐照后高等神经活动变化所遵循的主要规律。环境因素对受辐照机体的影响具有应激性质,并伴随着主要神经过程中中枢-中枢和中枢-外周关系的改变,其发病机制在一定程度上取决于突触能量传递速率的稳态水平变化,而突触能量传递速率又定量地取决于辐照机体在辐射损伤发展不同阶段的反应。在辐射损伤发展早期,突触传递速率分别为11.6、9.7和12.4(相对单位),对应于重带电粒子的辐射作用阶段,这使得能够定性和定量地比较重带电粒子辐照后各种执行形态功能结构的最终受体的反应。