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[辐照后延迟期重带电粒子小通量对大鼠大脑皮质神经元的影响]

[Effects of small fluxes of heavy charged particles on neurons of the rats' cerebral cortex in delayed periods following irradiation].

作者信息

Budennaia N N

机构信息

State Scientific Center RF, "Institute of Medico-Biological Problems".

出版信息

Aviakosm Ekolog Med. 1996;30(5):40-4.

PMID:8974599
Abstract

Dystrophic changes in neurons of the sensorimotor cortex of rat's brain in delayed periods following exposure to small fluxes, i.e. 104 and 105 particles/cm2, of accelerated carbon, fluorine, and oxygen ions with an energy of 300 MeV/nucleon and 137Cs gamma-rays at a dose of 1.0 Gy were quantitatively analyzed. Some structural changes of varying degree including death of a part of neurons were observed; however, most of the cells looked unaltered. Glial elements and small blood vessels also developed a reaction. Dynamics of the morphologic changes was studied. Higher effectiveness of small fluxes of heavy charged particles versus gamma-radiation at a dose of 1.0 Gy and dependence of the depth of structural disorders on linear energy transfer were demonstrated.

摘要

对大鼠大脑感觉运动皮层神经元在暴露于能量为300 MeV/核子的加速碳、氟和氧离子以及剂量为1.0 Gy的137Csγ射线的小通量(即104和105粒子/cm2)后的延迟期内的营养不良性变化进行了定量分析。观察到了不同程度的一些结构变化,包括一部分神经元死亡;然而,大多数细胞看起来未改变。神经胶质成分和小血管也出现了反应。研究了形态学变化的动态过程。证明了在1.0 Gy剂量下,重带电粒子小通量相对于γ辐射具有更高的有效性,以及结构紊乱深度对线性能量传递的依赖性。

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Aviakosm Ekolog Med. 1996;30(5):40-4.
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