Borens O, Nussbaumer F, Baalbaki R, Trampuz A
Département de l'appareil locomoteur, CHUV, Lausanne.
Rev Med Suisse. 2009 Dec 16;5(230):2563-8.
Infections associated with implants are increasingly important in modem medicine. Biofilms are the cause that these infections are more difficult to diagnose and to cure. Particularly low-grade infections are difficult to distinguish from aseptic failure, because they often present with early loosening and persisting pain. For an accurate diagnosis, clinical signs and symptoms, laboratory markers of infection, microbiology, histology and imaging examinations are needed. The treatment goal is eradication of infection and an optimal functional result. Successful treatment requires adequate surgical procedure combined with long-term antimicrobial therapy, ideally with an agent acting on biofilms.
与植入物相关的感染在现代医学中日益重要。生物膜是这些感染更难诊断和治愈的原因。特别是低度感染很难与无菌性失败区分开来，因为它们常常表现为早期松动和持续疼痛。为了进行准确诊断，需要临床体征和症状、感染的实验室标志物、微生物学、组织学和影像学检查。治疗目标是根除感染并获得最佳功能结果。成功的治疗需要适当的外科手术结合长期抗菌治疗，理想情况下使用作用于生物膜的药物。
