抗肿瘤药。573. 从蛱蝶科蝴蝶碧凤蝶中分离和结构鉴定的凤蝶菌素。
Antineoplastic agents. 573. isolation and structure of papilistatin from the papilionid butterfly Byasa polyeuctes termessa.
机构信息
Cancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University, PO Box 871604, Tempe, Arizona 85287-1604, USA.
出版信息
J Nat Prod. 2010 Feb 26;73(2):164-6. doi: 10.1021/np9004689.
Abstract
Bioassay-guided separation of an extract of the wings from a Taiwan butterfly, Byasa polyeuctes termessa, allowed isolation of a new cancer cell growth inhibitor designated papilistatin (1a). The structure was determined by analysis of 1D and 2D NMR spectra and by HRMS. Against a panel of six human and the murine P388 leukemia cancer cell lines, papilistatin exhibited cancer cell growth inhibition with GI(50)'s of 0.093-3.5 microg/mL. Papilistatin was also found to have antibacterial activity.
摘要
生物测定指导下分离台湾凤蝶翅膀提取物，得到一种新型的癌细胞生长抑制剂，命名为帕皮利斯坦（1a）。其结构通过 1D 和 2D NMR 谱分析和高分辨质谱确定。对六种人源和鼠源 P388 白血病癌细胞系进行活性测试，帕皮利斯坦对癌细胞生长的半数抑制浓度（GI50）为 0.093-3.5 微克/毫升。此外，帕皮利斯坦还具有抗菌活性。
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