[肿瘤坏死因子（TNF）对受辐照小鼠造血集落形成细胞恢复过程的作用]
[The action of the tumor necrosis factor (TNF) on the recovery processes of hemopoietic colony-forming cells in irradiated mice].
作者信息
Semina O V, Semenets T N, Chuvpilo S A, Korobko V G, Povererennyĭ A M
出版信息
Radiobiologiia. 1991 Jan-Feb;31(1):92-6.
The influence of a tumor-necrotic factor (TNF) on the CFUs population has been studied normally and after irradiation. An inhibitory effect on the pool of the seven-day and doubling of the yield of the eleven-day colonies have been observed in mice received TNF 20 h before bone marrow removal as compared with the controls. The kinetics of restoration of bone marrow cellularity and CFUs number in mouse donors treated with TNF 20 h before irradiation (5.0 Gy) has demonstrated the stimulatory effect of the agent on both indices.
已经研究了肿瘤坏死因子（TNF）对集落形成单位（CFU）群体在正常情况下以及照射后的影响。与对照组相比，在去除骨髓前20小时接受TNF的小鼠中，观察到对七天集落池有抑制作用，并且十一天集落产量增加了一倍。在照射（5.0 Gy）前20小时用TNF处理的小鼠供体中，骨髓细胞数量和CFU数量的恢复动力学表明该因子对这两个指标均有刺激作用。
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