L-脯氨酸在水介质中催化高效一锅法合成螺环氧化吲哚衍生物。
Efficient one-pot synthesis of spirooxindole derivatives catalyzed by L-proline in aqueous medium.
作者信息
Li Yuling, Chen Hui, Shi Chunling, Shi Daqing, Ji Shunjun
机构信息
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, PR China.
出版信息
J Comb Chem. 2010 Mar 8;12(2):231-7. doi: 10.1021/cc9001185.
PMID:20085353
Abstract
An efficient one-pot synthesis of spirooxindole derivatives by three-component reaction of isatins, malononitrile (cyanoacetic ester) and 1,3-dicarbonyl compounds in water in the presence of l-proline is reported. This new protocol has the advantages of environmental friendliness, higher yields, shorter reaction times, low cost, and convenient operation.
摘要
报道了在水相中，以L-脯氨酸为催化剂，通过靛红、丙二腈（氰基乙酸酯）和1,3-二羰基化合物的三组分反应高效一锅法合成螺吲哚啉衍生物。该新方法具有环境友好、产率高、反应时间短、成本低和操作简便等优点。
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