Atkin Deborah H, Trookman Nathan S, Rizer Ronald L, Schreck Linda E, Ho Elizabeth T, Gotz Vincent, Ford Rosanne O, Mehta Rahul C
Dermatology and Laser of Del Mar, Del Mar, CA, USA.
J Cosmet Laser Ther. 2010 Feb;12(1):14-20. doi: 10.3109/14764170903449786.
A 3-month, open-label, single-center study was conducted to determine whether a uniquely formulated and physiologically balanced topical treatment serum containing multiple growth factors, cytokines, peptides, antioxidants and depigmenting agents could improve the visible signs of facial photodamage. Thirty-seven females, aged 32-55 years, with mild to severe, fine and coarse peri-ocular wrinkles were enrolled and completed the study. Subjects applied the treatment serum to the face twice daily for 3 months in conjunction with a basic skincare regimen. Clinical evaluations of photodamage were performed at baseline and months 1, 2 and 3. Cutometer measurements and subject self-assessment questionnaires were also conducted during the study. Clinical evaluations showed statistically significant reductions in fine wrinkles and coarse wrinkles and improvements in skin texture, tone and radiance starting at month 1 with continued improvements at months 2 and 3. Cutometer readings showed decreased skin extensibility and increased resiliency. Subject self-assessments confirmed that the beneficial effects of the treatment serum were readily observed by the users. The treatment serum was well-tolerated with no treatment-related adverse events reported during the 3-month study. Use of this novel treatment serum produced significant improvements in the visible signs of facial photodamage.
开展了一项为期3个月的开放标签单中心研究，以确定一种含有多种生长因子、细胞因子、肽、抗氧化剂和色素沉着抑制剂的独特配方且生理平衡的局部治疗血清是否能改善面部光损伤的可见迹象。招募了37名年龄在32至55岁之间、有轻度至重度、细纹和粗纹眼周皱纹的女性并完成了研究。受试者在3个月内每天两次将治疗血清涂抹于面部，并结合基本护肤方案。在基线以及第1、2和3个月进行光损伤的临床评估。在研究期间还进行了皮肤弹性测定仪测量和受试者自我评估问卷。临床评估显示，从第1个月开始，细纹和粗纹在统计学上有显著减少，皮肤质地、色调和光泽有所改善，在第2个月和第3个月持续改善。皮肤弹性测定仪读数显示皮肤伸展性降低，弹性增加。受试者自我评估证实使用者很容易观察到治疗血清的有益效果。在为期3个月的研究期间，治疗血清耐受性良好，未报告与治疗相关的不良事件。使用这种新型治疗血清对面部光损伤的可见迹象有显著改善。
