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皮内注射生长因子前后皮肤粘弹性变化的研究

A Study on the Alterations in Skin Viscoelasticity before and after an Intradermal Administration of Growth Factor.

作者信息

Ono Ichiro

机构信息

Department of Dermatology, Sapporo Medical University School of Medicine, South-1 West16 Chuoku Sapporo, Hokkaido, Japan.

出版信息

J Cutan Aesthet Surg. 2011 May;4(2):98-104. doi: 10.4103/0974-2077.85022.

DOI:10.4103/0974-2077.85022
PMID:21976900
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3183736/
Abstract

BACKGROUND

While photo-aging is believed to be preventable by the complete blockage of ultraviolet rays, there is no epoch-making method except sing fillers or autologous fat injection, for rejuvenating the skin once it has aged.

OBJECTIVE

Our group developed a new method for rejuvenating aged skin by the direct intradermal injection of basic fibroblast growth factor, the first method of its kind in the world. In this paper we report the results of long-term follow-up observations and alterations in skin viscoelasticity before and after this treatment.

MATERIALS AND METHODS

A single dose of growth factor was injected directly into aged skin of the dorsal surface of the hand intradermally. The skin viscoelasticity of 50 treated cases was measured by a cutometer just before the treatment and at 1, 3, 6, and 9 months after treatment, respectively.

RESULTS

WE OBSERVED THE FOLLOWING REJUVENATING EFFECTS: improved skin softness, gradual improvement of turgor, improved thickness of atrophied skin, and greatly improved viscoelasticity which reveals the improvement of biomechanical properties of the treated aged skin. According to the comparisons of viscoelasticity between pre- and post-treatment, the rejuvenated changes of R2 and R7 values were comparable to an age difference of more than 20 years.

CONCLUSION

This method was confirmed to have excellent effects in rejuvenating aged skin safely and reliably including biomechanical properties. With this advance, we expect conventional non-physiological skin rejuvenating treatments to be replaced by a much more fundamental method using one-time injections of the growth factor.

摘要

背景

虽然人们认为通过完全阻挡紫外线可以预防光老化，但对于皮肤老化后恢复活力，除了使用填充剂或自体脂肪注射外，尚无开创性的方法。

目的

我们团队开发了一种通过皮内直接注射碱性成纤维细胞生长因子使老化皮肤恢复活力的新方法，这是世界上首创的此类方法。在本文中，我们报告了长期随访观察结果以及该治疗前后皮肤粘弹性的变化。

材料与方法

将单剂量生长因子直接皮内注射到手背部的老化皮肤中。分别在治疗前以及治疗后1、3、6和9个月，使用皮肤弹性测定仪测量50例治疗病例的皮肤粘弹性。

结果

我们观察到以下恢复活力的效果：皮肤柔软度改善、弹性逐渐改善、萎缩皮肤厚度增加以及粘弹性大幅改善，这表明治疗后的老化皮肤生物力学性能得到改善。根据治疗前后粘弹性的比较，R2和R7值的恢复活力变化相当于年龄相差超过20岁。

结论

该方法被证实对使老化皮肤恢复活力具有优异效果，包括生物力学性能方面，安全可靠。有了这一进展，我们期望传统的非生理性皮肤恢复活力治疗方法将被使用生长因子一次性注射的更基础方法所取代。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31a1/3183736/db470e14210a/JCAS-4-98-g010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31a1/3183736/8d78982e8090/JCAS-4-98-g006.jpg
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