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季节性和大流行性流感疫苗以及病毒生产基质变化的影响。

Vaccines against seasonal and pandemic influenza and the implications of changes in substrates for virus production.

机构信息

National Institute of Biological Standards and Control/Health Protection Agency, Hertfordshire, United Kingdom.

出版信息

Clin Infect Dis. 2010 Feb 15;50(4):560-5. doi: 10.1086/650171.

DOI:10.1086/650171
PMID:20085485
Abstract

Influenza virus changes constantly, making vaccine production challenging. Changing the growth substrate from eggs to cell culture raises issues at all stages of the process, from surveillance to the assay of vaccines. The pandemic threat-first H5N1, then H1N1-encouraged a review of methods and brought issues into sharp relief.

摘要

流感病毒不断变化，使得疫苗生产具有挑战性。将生长基质从鸡蛋改为细胞培养会在从监测到疫苗检测的各个阶段引发问题。大流行的威胁——先是 H5N1，然后是 H1N1——促使人们对方法进行了审查，并使问题更加突出。

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