细胞培养作为流感疫苗生产的基质：世界卫生组织会议纪要
Cell culture as a substrate for the production of influenza vaccines: memorandum from a WHO meeting.
出版信息
Bull World Health Organ. 1995;73(4):431-5.
Abstract
Influenza has been a significant public health problem worldwide, with three pandemics during the past century. Immunization is the most effective measure to control an influenza pandemic. Since rapid production of large amounts of influenza vaccine depends on the availability of fertile hens' eggs to grow the viruses, there is an urgent need for the development of alternative cell culture systems, which would allow rapid scale-up of production in the event of a pandemic. This WHO meeting discussed the results of studies from several laboratories on the cultivation of influenza viruses in stable cell lines, and made recommendations for further work.
摘要
流感一直是全球重大的公共卫生问题，在过去一个世纪里曾发生过三次大流行。免疫接种是控制流感大流行的最有效措施。由于大量流感疫苗的快速生产依赖于用于培养病毒的受精鸡蛋的供应，因此迫切需要开发替代细胞培养系统，以便在大流行发生时能够迅速扩大生产规模。本次世界卫生组织会议讨论了多个实验室关于在稳定细胞系中培养流感病毒的研究结果，并为进一步的工作提出了建议。
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