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Genetic study of human cells in vitro. Carbohydrate variants from cultures of HeLa and conjunctival cells.人类细胞的体外遗传学研究。来自海拉细胞和结膜细胞培养物的碳水化合物变体。
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Comparison of 10 influenza A (H1N1 and H3N2) haemagglutinin sequences obtained directly from clinical specimens to those of MDCK cell- and egg-grown viruses.直接从临床标本中获得的10个甲型流感病毒（H1N1和H3N2）血凝素序列与在MDCK细胞和鸡胚中培养的病毒的血凝素序列的比较。
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Cell tropism of influenza virus mediated by hemagglutinin activation at the stage of virus entry.病毒进入阶段血凝素激活介导的流感病毒细胞嗜性
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Impairment of multicycle influenza virus growth in Vero (WHO) cells by loss of trypsin activity.胰蛋白酶活性丧失导致多周期流感病毒在Vero（世卫组织）细胞中的生长受损。
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Cytotechnology. 1994;14(1):47-59. doi: 10.1007/BF00772195.
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Gene composition of high-yielding influenza vaccine strains obtained by recombination.通过重组获得的高产流感疫苗株的基因组成。
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8
Isolation and preliminary characterization of a highly cytolytic influenza B virus variant with an aberrant NS gene.一株具有异常NS基因的高细胞溶解性乙型流感病毒变体的分离与初步鉴定
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细胞培养作为流感疫苗生产的基质：世界卫生组织会议纪要

Cell culture as a substrate for the production of influenza vaccines: memorandum from a WHO meeting.

出版信息

Bull World Health Organ. 1995;73(4):431-5.

PMID:7554013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2486787/
Abstract

Influenza has been a significant public health problem worldwide, with three pandemics during the past century. Immunization is the most effective measure to control an influenza pandemic. Since rapid production of large amounts of influenza vaccine depends on the availability of fertile hens' eggs to grow the viruses, there is an urgent need for the development of alternative cell culture systems, which would allow rapid scale-up of production in the event of a pandemic. This WHO meeting discussed the results of studies from several laboratories on the cultivation of influenza viruses in stable cell lines, and made recommendations for further work.

摘要

流感一直是全球重大的公共卫生问题，在过去一个世纪里曾发生过三次大流行。免疫接种是控制流感大流行的最有效措施。由于大量流感疫苗的快速生产依赖于用于培养病毒的受精鸡蛋的供应，因此迫切需要开发替代细胞培养系统，以便在大流行发生时能够迅速扩大生产规模。本次世界卫生组织会议讨论了多个实验室关于在稳定细胞系中培养流感病毒的研究结果，并为进一步的工作提出了建议。