Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy.
Clin Exp Allergy. 2009 Dec;39(12):1815-21. doi: 10.1111/j.1365-2222.2009.03385.x.
Asthma is a chronic inflammatory disease of the airways characterized by infiltration and activation of inflammatory cells and by structural changes, including subepithelial fibrosis, smooth muscle cells hypertrophy/hyperplasia, epithelial cell metaplasia and angiogenesis. These structural changes are thought to correlate with asthma severity and to account for the development of progressive lung function deterioration. The mechanism underlying airway angiogenesis in asthma and its precise clinical relevance have not yet been completely elucidated. This review provides recent data showing the contribution of allergic inflammation in increased airway vascularity and potential therapeutical approaches in asthma treatment by acting on bronchial microvascular changes.
哮喘是一种气道的慢性炎症性疾病，其特征是炎症细胞的浸润和激活，以及结构改变，包括上皮下纤维化、平滑肌细胞肥大/增生、上皮细胞化生和血管生成。这些结构改变被认为与哮喘的严重程度相关，并解释了肺功能进行性恶化的发生。哮喘气道血管生成的机制及其确切的临床意义尚未完全阐明。这篇综述提供了最新的数据，表明过敏炎症在增加气道血管生成中的作用，以及通过作用于支气管微血管改变来治疗哮喘的潜在治疗方法。
