Department of Internal Medicine, Chungnam National University School of Medicine, Jeonju, South Korea.
Respirology. 2010 Apr;15(3):459-71. doi: 10.1111/j.1440-1843.2010.01724.x. Epub 2010 Mar 19.
Asthma is a chronic inflammatory disease of airways, characterized by airway hyperresponsiveness and airflow limitation with acute bronchoconstriction, swelling of the airway wall, chronic mucus plug formation and airway wall remodelling. Functional and structural changes in the vasculature of asthmatic airways have been documented, and the signalling mechanisms are complex and have recently attracted much attention. The vascular changes may affect inflammatory cell recruitment, airway hyperresponsiveness and the regulation of airway calibre, and further, the level of disease control. Many critical factors are involved in the pathophysiological regulation of vascular changes in bronchial asthma, and the actions of these factors must be very carefully orchestrated. By better understanding the complicated actions of each factor, we may be able to advance further in asthma treatment.
哮喘是一种气道的慢性炎症性疾病，其特征是气道高反应性和气流受限伴急性支气管痉挛、气道壁肿胀、慢性黏液栓形成和气道壁重塑。已经记录了哮喘气道中血管的功能和结构变化，其信号机制复杂，最近引起了广泛关注。血管变化可能影响炎症细胞募集、气道高反应性和气道口径的调节，进一步影响疾病的控制水平。许多关键因素参与了支气管哮喘中血管变化的病理生理调节，这些因素的作用必须非常精细地协调。通过更好地理解每个因素的复杂作用，我们可能能够在哮喘治疗方面取得进一步进展。
