Dussaix E, Le Coz Y
Laboratoire de virologie, hôpital de Bicêtre, Le Kremlin-Bicêtre.
Rev Prat. 1991 Feb 1;41(4):332-5.
Some viral infections, such as rubella, cytomegalovirus and parvovirus B 19 infections or varicella, are particularly feared in pregnant women in view of the risk of foetal infection. Laboratory tests play an important role since there is no other way of diagnosing the infection and determining whether it is primary or secondary, a distinction which to a great extent conditions the severity of the foetal disease. However, no virological diagnosis can be made unless the examinations needed are prescribed correctly and at the right moment. The diagnosis of rubella is now well codified, but that of CMV infection still suffers from interpretation problems and that of parvovirus B 19 infection can only be obtained from specialized laboratories. The application of rapid diagnostic methods and molecular biology to foetal specimen collected under ultrasonography should provide a more accurate prenatal diagnosis of congenital viral infections.
某些病毒感染，如风疹、巨细胞病毒、细小病毒B19感染或水痘，鉴于存在胎儿感染风险，在孕妇中尤其令人担忧。实验室检查发挥着重要作用，因为没有其他方法可以诊断感染并确定其是原发性还是继发性，而这一区分在很大程度上决定了胎儿疾病的严重程度。然而，除非所需检查得到正确的开具和在恰当的时机进行，否则无法做出病毒学诊断。风疹的诊断现已规范明确，但巨细胞病毒感染的诊断仍存在解读问题，细小病毒B19感染的诊断只能从专业实验室获得。将快速诊断方法和分子生物学应用于超声引导下采集的胎儿标本，应能提供更准确的先天性病毒感染产前诊断。
