冠心病患者体内海洋 ω-3 脂肪酸水平与端粒衰老的关联。
Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease.
机构信息
Division of Cardiology, Room 5G1, San Francisco General Hospital, 1001 Potrero Ave, San Francisco, CA 94110, USA.
出版信息
JAMA. 2010 Jan 20;303(3):250-7. doi: 10.1001/jama.2009.2008.
CONTEXT
Increased dietary intake of marine omega-3 fatty acids is associated with prolonged survival in patients with coronary heart disease. However, the mechanisms underlying this protective effect are poorly understood.
OBJECTIVE
To investigate the association of omega-3 fatty acid blood levels with temporal changes in telomere length, an emerging marker of biological age.
DESIGN, SETTING, AND PARTICIPANTS: Prospective cohort study of 608 ambulatory outpatients in California with stable coronary artery disease recruited from the Heart and Soul Study between September 2000 and December 2002 and followed up to January 2009 (median, 6.0 years; range, 5.0-8.1 years).
MAIN OUTCOME MEASURES
We measured leukocyte telomere length at baseline and again after 5 years of follow-up. Multivariable linear and logistic regression models were used to investigate the association of baseline levels of omega-3 fatty acids (docosahexaenoic acid [DHA] and eicosapentaenoic acid [EPA]) with subsequent change in telomere length.
RESULTS
Individuals in the lowest quartile of DHA+EPA experienced the fastest rate of telomere shortening (0.13 telomere-to-single-copy gene ratio [T/S] units over 5 years; 95% confidence interval [CI], 0.09-0.17), whereas those in the highest quartile experienced the slowest rate of telomere shortening (0.05 T/S units over 5 years; 95% CI, 0.02-0.08; P < .001 for linear trend across quartiles). Levels of DHA+EPA were associated with less telomere shortening before (unadjusted beta coefficient x 10(-3) = 0.06; 95% CI, 0.02-0.10) and after (adjusted beta coefficient x 10(-3) = 0.05; 95% CI, 0.01-0.08) sequential adjustment for established risk factors and potential confounders. Each 1-SD increase in DHA+EPA levels was associated with a 32% reduction in the odds of telomere shortening (adjusted odds ratio, 0.68; 95% CI, 0.47-0.98).
CONCLUSION
Among this cohort of patients with coronary artery disease, there was an inverse relationship between baseline blood levels of marine omega-3 fatty acids and the rate of telomere shortening over 5 years.
背景
增加膳食中海洋 ω-3 脂肪酸的摄入量与冠心病患者的生存时间延长有关。然而，这种保护作用的机制尚不清楚。
目的
研究 ω-3 脂肪酸血液水平与端粒长度随时间变化的关系，端粒长度是生物年龄的一个新兴标志物。
设计、地点和参与者：这是一项前瞻性队列研究，纳入了 2000 年 9 月至 2002 年 12 月期间在加利福尼亚州参加心脏与灵魂研究的 608 名稳定型冠状动脉疾病的门诊患者，并随访至 2009 年 1 月（中位数为 6.0 年；范围为 5.0-8.1 年）。
主要观察指标
我们在基线和随访 5 年后测量白细胞端粒长度。多变量线性和逻辑回归模型用于研究基线 ω-3 脂肪酸（二十二碳六烯酸[DHA]和二十碳五烯酸[EPA]）水平与随后端粒长度变化的关系。
结果
DHA+EPA 最低四分位数的个体经历了最快的端粒缩短速度（5 年内 0.13 个端粒-单拷贝基因比值[T/S]单位；95%置信区间[CI]，0.09-0.17），而 DHA+EPA 最高四分位数的个体经历了最慢的端粒缩短速度（5 年内 0.05 T/S 单位；95%CI，0.02-0.08；四分位区间线性趋势 P <.001）。DHA+EPA 水平与未经调整（校正系数 x 10(-3) = 0.06；95%CI，0.02-0.10）和调整后（校正系数 x 10(-3) = 0.05；95%CI，0.01-0.08）的既定风险因素和潜在混杂因素后端粒缩短有关。DHA+EPA 水平每增加 1-SD，端粒缩短的几率就会降低 32%（校正比值比，0.68；95%CI，0.47-0.98）。
结论
在这组患有冠状动脉疾病的患者中，基线血液中海洋 ω-3 脂肪酸水平与 5 年内端粒缩短率呈负相关。
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