Yamaoka Ippei, Hagi Mieko, Doi Masako
Research and Development Center, New Business and Development Department, Otsuka Pharmaceutical Factory, Inc, Naruto, Tokushima, Japan.
J Nutr Sci Vitaminol (Tokyo). 2009 Dec;55(6):511-7. doi: 10.3177/jnsv.55.511.
Ingestion of a high-protein meal results in body weight loss due to elevated energy expenditure, while also increasing satiety and decreasing subsequent food intake. The present study aimed to clarify the effects of a high-protein, carbohydrate-free diet (HPCFD) on these physiological indicators from a circadian perspective. Rats were given HPCFD or a pair-fed normal protein content diet (20% protein; NPD) for 4 d. The HPCFD group lost more body weight than the NPD group. Oxygen consumption (VO(2)) in the HPCFD group did not change during the experimental period, and tended to be higher during the light (L) phase than in the NPD group. Carbon dioxide production (VCO(2)) during the L phase was higher in the HPCFD group than in the NPD group, where VCO(2) was gradually decreased during the last dark (D) phase and throughout the L phase. The HPCFD group exhibited higher daily core body temperature (T(b)), particularly during the late D phase and throughout the L phase when compared to the NPD group. Locomotor activities during the D phase of the NPD group tended to gradually increase and were thus significantly higher than in the HPCFD group. These results suggest that HPCFD, even if energy intake is insufficient, maintains circadian changes in metabolic rates, resulting in maintenance of elevated daily T(b) and body weight reduction without increasing activity.
摄入高蛋白餐会因能量消耗增加而导致体重减轻，同时还会增加饱腹感并减少后续食物摄入量。本研究旨在从昼夜节律的角度阐明无碳水化合物高蛋白饮食（HPCFD）对这些生理指标的影响。给大鼠喂食HPCFD或配对喂养的正常蛋白质含量饮食（20%蛋白质；NPD），持续4天。HPCFD组比NPD组体重减轻更多。HPCFD组的耗氧量（VO₂）在实验期间没有变化，并且在光照（L）期比NPD组更高。HPCFD组在L期的二氧化碳产生量（VCO₂）高于NPD组，而NPD组的VCO₂在最后一个黑暗（D）期和整个L期逐渐降低。与NPD组相比，HPCFD组的每日核心体温（Tₐ）更高，特别是在D期后期和整个L期。NPD组在D期的运动活动倾向于逐渐增加，因此显著高于HPCFD组。这些结果表明，即使能量摄入不足，HPCFD仍能维持代谢率的昼夜变化，从而在不增加活动量的情况下维持每日Tₐ升高和体重减轻。
