[一例晚期胃癌伴多发肝转移对紫杉醇联合S-1治疗长期完全缓解的病例]

[A case of advanced gastric cancer with multiple liver metastases completely responding long term to paclitaxel plus S-1 therapy].

作者信息

Kanou Mikihiro, Kurisu Yoshihiro, Akagi Shinji, Tanaka Tomoko, Toge Kunio

机构信息

Department of Surgery, Mazda Motor Coorporation Mazda Hospital, Japan.

出版信息

Gan To Kagaku Ryoho. 2010 Jan;37(1):143-5.

Abstract

A 69-year-old man was admitted to our hospital with complaints of loss of appetite, fatigue and dysphasia. Upper gastroscopy revealed advanced gastric cancer. Abdominal CT suggested liver metastases. At first we thought the liver metastases has been completely resected, but we found multiple liver metastases unexpectedly. So only total gastric resection and liver biopsy were performed. The pathological diagnosis was metastatic carcinoma. Paclitaxel (PTX) and S-1 combination chemotherapy was started after operation and was continued for 42 courses. A CT scan showed a complete response, and he has been well without tumor re-growth ever since. The combination of PTX and S-1 not only may be an effective regimen for gastric cancer with liver metastases, but also can be used without side effects for a long time.

摘要

一名69岁男性因食欲不振、疲劳和吞咽困难入院。上消化道内镜检查显示为进展期胃癌。腹部CT提示肝转移。起初我们认为肝转移灶已完全切除，但意外发现多处肝转移。因此仅进行了全胃切除和肝活检。病理诊断为转移性癌。术后开始使用紫杉醇（PTX）和S-1联合化疗，并持续了42个疗程。CT扫描显示完全缓解，此后他一直状况良好，未出现肿瘤复发。PTX和S-1联合不仅可能是治疗伴有肝转移胃癌的有效方案，而且可以长期使用且无副作用。

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