Université de Lyon, INSERM, U851, Université Lyon 1, IFR128, Lyon, France.
Autophagy. 2010 Feb;6(2):299-300. doi: 10.4161/auto.6.2.11132. Epub 2010 Feb 6.
Autophagy is a degradative mechanism involved in cell protection against invading pathogens. Although the autophagic process is well characterized, the molecular pathways leading to its activation upon pathogen binding remain poorly understood. Our recent work demonstrates that the cell surface pathogen receptor CD46 induces autophagy upon pathogen recognition. The molecular pathway linking CD46 to the autophagosome machinery relies on the scaffold protein GOPC and on the autophagosome formation complex Beclin 1/VPS34. The CD46-dependent autophagy is critical to an early control of infection.
自噬是一种参与细胞抵御入侵病原体的降解机制。尽管自噬过程已经得到很好的描述，但导致其在病原体结合时被激活的分子途径仍知之甚少。我们最近的工作表明，细胞表面病原体受体 CD46 在病原体识别后诱导自噬。将 CD46 与自噬体机制联系起来的分子途径依赖于支架蛋白 GOPC 和自噬体形成复合物 Beclin 1/VPS34。CD46 依赖性自噬对于早期控制感染至关重要。
