Yang Xinxin, Song Lu, Liu Zhenguo
Department of Neurology, Xinhua Hospital Affiliated To Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Neuroreport. 2010 Mar 10;21(4):268-72. doi: 10.1097/WNR.0b013e328335b411.
This study was undertaken to investigate the neuroprotective effects of repetitive transcranial magnetic stimulation (rTMS) on 6-hydroxydopamine (6-OHDA)-induced rats with Parkinson's disease. rTMS was given to rats with Parkinson's disease induced by 6-OHDA, daily for 4 weeks to examine the protective effects. Rotational test showed that rTMS significantly attenuated apomorphine-induced turns in rats with Parkinson's disease. Tissue processing showed that rTMS alleviated 6-OHDA-induced loss of dopaminergic neurons in rat substantia nigra. Furthermore, rTMS decreased the levels of cyclooxygenase-2 and tumor necrosis factor-alpha in rat substantia nigra, and prevented the fall of dopamine in the striatum of rats with Parkinson's disease.
本研究旨在探讨重复经颅磁刺激（rTMS）对6-羟基多巴胺（6-OHDA）诱导的帕金森病大鼠的神经保护作用。对6-OHDA诱导的帕金森病大鼠给予rTMS，每日一次，持续4周，以检测其保护作用。旋转试验表明，rTMS显著减轻了帕金森病大鼠阿扑吗啡诱导的旋转。组织处理显示，rTMS减轻了6-OHDA诱导的大鼠黑质多巴胺能神经元损失。此外，rTMS降低了大鼠黑质中环氧合酶-2和肿瘤坏死因子-α的水平，并防止了帕金森病大鼠纹状体中多巴胺水平的下降。
