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星形胶质细胞网络:神经胶质和神经血管相互作用的进一步研究。

Astroglial networks: a step further in neuroglial and gliovascular interactions.

机构信息

INSERM U840, Collège de France, 75005 Paris, France.

出版信息

Nat Rev Neurosci. 2010 Feb;11(2):87-99. doi: 10.1038/nrn2757.

DOI:10.1038/nrn2757
PMID:20087359
Abstract

Dynamic aspects of interactions between astrocytes, neurons and the vasculature have recently been in the neuroscience spotlight. It has emerged that not only neurons but also astrocytes are organized into networks. Whereas neuronal networks exchange information through electrical and chemical synapses, astrocytes are interconnected through gap junction channels that are regulated by extra- and intracellular signals and allow exchange of information. This intercellular communication between glia has implications for neuroglial and gliovascular interactions and hence has added another level of complexity to our understanding of brain function.

摘要

星形胶质细胞、神经元和血管之间相互作用的动态方面最近成为神经科学的焦点。研究表明,不仅神经元,而且星形胶质细胞也被组织成网络。虽然神经元网络通过电和化学突触交换信息,但星形胶质细胞通过缝隙连接通道相互连接,这些通道受细胞外和细胞内信号的调节,允许信息交换。这种胶质细胞之间的细胞间通讯对神经胶质和神经血管相互作用有影响,因此为我们对大脑功能的理解增加了另一个复杂层面。

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