Wiggers P, Dalhøj J, Nielsen G D, Grandjean P A, Hørder M
Klinisk institut, Odense Sygehus.
Ugeskr Laeger. 1991 Feb 25;153(9):646-8.
In order to assess the prevalence of iron deficiency in the Danish population, a randomised cross sectional investigation was carried out one year after repealing of the order from 1939 concerning supplementing of corn products with iron. A randomised group of 198 persons divided into ten groups of 20 persons with equal numbers of men and women in the age group 20-69 years was submitted to determinations of serum-iron, serum-transferrin and serum-ferritin. The prevalence of iron deficiency as determined by serum-ferritin values of below 15 micrograms/l was 18% and 12% respectively, for women under and over 45 years while iron deficiency determined by transferrin saturation under 16% was 18% for both groups. 6% of the women under 45 years had severe iron deficiency as determined by low transferrin saturation and low ferritin. The prevalence among men was 1% and 3% as assessed by serum-ferritin levels and transferritin saturation. These results were compared with corresponding population investigations from Sweden where iron enrichment is the highest in the world and the sale of iron tablets is the greatest in the world. No significant differences in the frequency of latent iron deficiency could be demonstrated but the number of persons with severe iron depletion appears to be less in Sweden. Differences in the methodological procedures, however, cannot be excluded.
为评估丹麦人群中铁缺乏症的患病率,在废除1939年关于在玉米制品中添加铁的法令一年后,开展了一项随机横断面调查。随机选取了198人,分为十组,每组20人,年龄在20 - 69岁之间,男女数量相等,对其进行血清铁、血清转铁蛋白和血清铁蛋白的测定。血清铁蛋白值低于15微克/升所确定的铁缺乏症患病率,45岁及以下女性和45岁以上女性分别为18%和12%;转铁蛋白饱和度低于16%所确定的铁缺乏症患病率,两组均为18%。45岁及以下女性中,6%因转铁蛋白饱和度低和铁蛋白低而患有严重铁缺乏症。男性中铁缺乏症患病率,根据血清铁蛋白水平和转铁蛋白饱和度评估分别为1%和3%。将这些结果与来自瑞典的相应人群调查结果进行了比较,瑞典是世界上铁强化程度最高且铁剂销售量最大的国家。未发现潜在铁缺乏症发生率存在显著差异,但瑞典严重铁缺乏的人数似乎较少。然而,不能排除方法程序上的差异。