Gál Brigitta, Dulic Sonja, Kiss Mária, Groma Gergely, Kovács László, Kemény Lajos, Bata-Csörgő Zsuzsanna
Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary.
Department of Rheumatology, University of Szeged, Szeged, Hungary.
J Dermatol. 2017 Apr;44(4):370-374. doi: 10.1111/1346-8138.13667. Epub 2016 Oct 28.
In psoriatic skin, laminin integrity is altered, which could lead to insufficient laminin integrin interactions, leaving the α6-integrin exposed and possibly accessible for autoantibody production. Therefore we investigated the presence of anti-α6-integrin autoantibodies in the serum of patients with psoriasis vulgaris (Ps), psoriatic arthritis (PsA) and rheumatoid arthritis (RA) in comparison with healthy donors. The level of circulating anti-α6-integrin antibodies was determined by enzyme-linked immunoassay using α6-integrin fragments. Antibodies against at least one recombinant fragment were found in approximately 30% of Ps and PsA patients. In contrast, in RA patients, the frequency of antibodies was similar to healthy controls. Our study shows the presence of anti-α6-integrin antibodies in Ps and PsA but not in RA, which could indicate ongoing abnormal processes in the skin. Anti-α6-integrin autoantibodies may contribute to the formation of micro-wounds in the skin and to the characteristic wound-healing phenotype in psoriasis.
在银屑病皮肤中，层粘连蛋白的完整性发生改变，这可能导致层粘连蛋白与整合素的相互作用不足，使α6整合素暴露，可能会引发自身抗体的产生。因此，我们研究了寻常型银屑病（Ps）、银屑病关节炎（PsA）和类风湿关节炎（RA）患者血清中抗α6整合素自身抗体的存在情况，并与健康供体进行比较。使用α6整合素片段通过酶联免疫吸附测定法测定循环抗α6整合素抗体的水平。在大约30%的Ps和PsA患者中发现了针对至少一种重组片段的抗体。相比之下，在RA患者中，抗体频率与健康对照相似。我们的研究表明，Ps和PsA患者存在抗α6整合素抗体，而RA患者不存在，这可能表明皮肤中存在持续的异常过程。抗α6整合素自身抗体可能有助于皮肤微伤口的形成以及银屑病中特征性的伤口愈合表型。
