Department of Dermatology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
Clin Exp Dermatol. 2010 Jun;35(4):e137-40. doi: 10.1111/j.1365-2230.2009.03773.x. Epub 2010 Jan 18.
It is thought that many people with nickel dermatitis use nail varnish as a barrier coat on nickel-containing metals; however, nail varnish allergy at sites in contact with such coated has only been documented once previously, to our knowledge. The aim of this study was to search for a possible link between nail varnish and metal allergy. In total, 1607 consecutively patch-tested patients were enrolled; 16 (1%) of these had nail varnish allergy, located mainly on the eyelids. Eight also had nickel allergy. Six of these eight had successfully used protective nail varnish on metals until subsequent development of 'failure of protection' even before the eyelid eczema developed. Sites in contact with metal might be a hidden and even initial localization for nail varnish allergy. 'Failure of protection' after a successful protective period despite renewing nail varnish coatings should raise suspicion of sensitization to the nail varnish itself. Future studies should focus on the incidence of allergic contact dermatitis and primary sensitization from nail varnish used as a barrier against nickel dermatitis.
据认为，许多患有镍性皮炎的人会在含镍金属上使用指甲油作为屏障涂层；然而，据我们所知，此前仅在接触此类涂层的部位记录过一次指甲油过敏。本研究旨在寻找指甲油和金属过敏之间的可能联系。共有 1607 名连续接受斑贴试验的患者被纳入研究；其中 16 名（1%）患者有指甲油过敏，主要位于眼睑。其中 8 人还患有镍过敏。这 8 人中的 6 人曾成功地在金属上使用保护性指甲油，直到随后在眼睑湿疹出现之前，甚至在保护性指甲油涂层更新之前，出现了“保护失效”。与金属接触的部位可能是指甲油过敏的隐匿性甚至初始部位。尽管重新涂抹了指甲油涂层，但在成功的保护期后出现“保护失效”，应怀疑对指甲油本身过敏。未来的研究应集中在用作镍性皮炎屏障的指甲油引起的过敏性接触性皮炎和原发性致敏的发生率上。
