Marsh G M, Leviton L C, Talbott E O, Callahan C, Pavlock D, Hemstreet G, Logue J N, Fox J, Schulte P
Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, PA 15261.
Am J Ind Med. 1991;19(3):291-301. doi: 10.1002/ajim.4700190304.
A medical surveillance program and epidemiologic study of 408 former workers of the Drake Chemical Company (now a Superfund waste site) was established in 1986. The Drake Health Registry Study was initiated because these workers had probable past exposures to beta-naphthylamine (BNA), a potent bladder carcinogen. The registry is widely viewed as a model for notification of workers at high risk of disease due to past occupational exposures. By the 40th month, 90% of the 366 living workers had been notified of the existence of the registry; 262 had been enrolled in the annual or semi-annual screening for bladder cancer. Among these, 27 persons have had abnormal screening results indicating moderate to high risk of bladder cancer and have been made eligible for further diagnostic tests. While no invasive bladder tumors were found among 18 persons completing the extended diagnostic evaluation, two diagnoses of moderate to severe dysplasia have been made. The registry has also identified three living and three deceased cases of bladder cancer in the cohort; a mortality analysis showed a 20- to 30-fold excess of bladder cancer. An incidence projection, based on the six identified cases, reveals that between six and ten new bladder cancer cases are likely to occur among the Drake cohort over the next 20 year period.
1986年，针对德雷克化学公司（现为超级基金污染场地）的408名前员工启动了一项医学监测计划和流行病学研究。启动德雷克健康登记研究是因为这些工人过去可能接触过β-萘胺（BNA），一种强效膀胱致癌物。该登记处被广泛视为因过去职业接触而处于疾病高风险的工人通知模型。到第40个月时，366名在世工人中有90%已被告知登记处的存在；262人已参加了膀胱癌年度或半年筛查。其中，27人的筛查结果异常，表明患膀胱癌的风险为中度至高度，并有资格接受进一步的诊断测试。在完成扩展诊断评估的18人中未发现侵袭性膀胱肿瘤，但已确诊两例中度至重度发育异常。登记处还在该队列中确定了3例在世和3例已故膀胱癌病例；死亡率分析显示膀胱癌的发病率高出20至30倍。根据已确定的6例病例进行的发病率预测显示，在未来20年期间，德雷克队列中可能会出现6至10例新的膀胱癌病例。
