Marsh G M, Callahan C, Pavlock D, Leviton L C, Talbott E O, Hemstreet G
Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, PA 15261.
J Occup Med. 1990 Sep;32(9):881-6. doi: 10.1097/00043764-199009000-00025.
In 1986, the Drake Health Registry Study initiated bladder cancer screening for 366 persons at high risk because of occupational exposure to beta-naphthylamine. The Drake Health Registry Study screening protocol consists of urinalysis, Papanicolaou cytology, and quantitative fluorescence image analysis. A positive screening test qualifies participants for a full diagnostic evaluation. The screening protocol has been modified during the first 3 years of the program's existence to address unexpected patterns of test results and to incorporate advances in screening technology. The current protocol, which has a two-tiered screening schedule, has been utilized successfully for 15 months. Of the 26 positive results to date most have been based on abnormal Papanicolaou cytology and/or quantitative fluorescence image analysis. Bladder abnormalities were cited among most of the 18 study members who underwent diagnostic evaluation, including chronic cystitis, inflammation, hyperplasia, and dysplasia. We conclude that the screening program is detecting very early changes in a relatively young cohort and that these persons must be monitored over a number of years to ensure adequate medical surveillance.
1986年，德雷克健康登记研究对366名因职业接触β-萘胺而处于高风险的人群启动了膀胱癌筛查。德雷克健康登记研究的筛查方案包括尿液分析、巴氏细胞学检查和定量荧光图像分析。筛查试验呈阳性的参与者有资格接受全面的诊断评估。在该项目开展的头3年里，筛查方案进行了修改，以应对意外的检测结果模式，并纳入筛查技术的进展。目前的方案采用了两级筛查时间表，已成功使用了15个月。在迄今为止的26个阳性结果中，大多数是基于异常的巴氏细胞学检查和/或定量荧光图像分析。在接受诊断评估的18名研究成员中，大多数都被查出膀胱异常，包括慢性膀胱炎、炎症、增生和发育异常。我们得出结论，筛查项目正在检测相对年轻队列中的非常早期的变化，并且必须对这些人进行数年的监测，以确保充分的医疗监督。
