The Department of Surgery, Burn and Shock Trauma Institute, Maywood, Illinois, USA.
J Surg Res. 2011 Jun 15;168(2):325-33.e1. doi: 10.1016/j.jss.2009.09.030. Epub 2009 Oct 9.
Here, we report the novel observation that natural killer T (NKT) cells contribute to the cutaneous wound repair process. Using an excisional wound model in wild-type versus NKT cell-deficient mice, this report shows that when NKT cells are absent, initial wound closure is markedly accelerated. We report here for the first time that NKT cells are a significant constituent of early wound inflammation and that they regulate the local production of a key subset of neutrophil and monocyte/macrophage chemokines, as well as TGF-β1 content and collagen deposition. Together, our findings support the concept that NKT cells regulate the early inflammatory and fibroproliferative phases of nonpathologic healing wounds, positioning the NKT cell as an attractive potential therapeutic target for modulation of impaired wound healing.
在这里，我们报告了一个新的观察结果，即自然杀伤 T（NKT）细胞有助于皮肤伤口修复过程。通过在野生型和 NKT 细胞缺陷型小鼠中的切除性伤口模型，本报告表明，当 NKT 细胞缺失时，初始伤口闭合明显加快。我们首次报道 NKT 细胞是早期伤口炎症的重要组成部分，它们调节关键的中性粒细胞和单核细胞/巨噬细胞趋化因子子集的局部产生，以及 TGF-β1 含量和胶原沉积。总之，我们的研究结果支持这样的概念，即 NKT 细胞调节非病理性愈合伤口的早期炎症和纤维增生阶段，使 NKT 细胞成为调节受损伤口愈合的有吸引力的潜在治疗靶点。
