双向作用：通过CD1d依赖性自然杀伤T细胞进行免疫调节。
Going both ways: immune regulation via CD1d-dependent NKT cells.
作者信息
Godfrey Dale I, Kronenberg Mitchell
机构信息
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia.
出版信息
J Clin Invest. 2004 Nov;114(10):1379-88. doi: 10.1172/JCI23594.
Abstract
NKT cells are a unique T lymphocyte sublineage that has been implicated in the regulation of immune responses associated with a broad range of diseases, including autoimmunity, infectious diseases, and cancer. In stark contrast to both conventional T lymphocytes and other types of Tregs, NKT cells are reactive to the nonclassical class I antigen-presenting molecule CD1d, and they recognize glycolipid antigens rather than peptides. Moreover, they can either up- or downregulate immune responses by promoting the secretion of Th1, Th2, or immune regulatory cytokines. This review will explore the diverse influences of these cells in various disease models, their ability to suppress or enhance immunity, and the potential for manipulating these cells as a novel form of immunotherapy.
摘要
自然杀伤T细胞（NKT细胞）是一种独特的T淋巴细胞亚群，与包括自身免疫性疾病、感染性疾病和癌症在内的多种疾病相关的免疫反应调节有关。与传统T淋巴细胞和其他类型的调节性T细胞（Tregs）形成鲜明对比的是，NKT细胞对非经典的I类抗原呈递分子CD1d有反应，并且它们识别糖脂抗原而非肽。此外，它们可以通过促进Th1、Th2或免疫调节细胞因子的分泌来上调或下调免疫反应。本综述将探讨这些细胞在各种疾病模型中的不同影响、它们抑制或增强免疫的能力，以及将这些细胞作为一种新型免疫疗法进行操控的潜力。
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