Department of Medical and Surgical Sciences, University of Otago, PO Box 913, Dunedin 9054, New Zealand.
J Clin Neurosci. 2010 Mar;17(3):315-9. doi: 10.1016/j.jocn.2009.06.026. Epub 2010 Jan 25.
The corpus callosum (CC) is thought to be especially vulnerable in traumatic brain injury. Bimanual cost (a slowing of reaction time with bimanual compared to unimanual responses) is a sensitive indicator of CC function. To determine whether CC dysfunction is a significant feature of mild traumatic brain injury, unimanual and bimanual reaction times were studied in 10 recently concussed patients and 10 healthy participants. Reaction times were studied within 1 week of concussion and again after 1 month. Concussion symptoms were assessed with the Rivermead Postconcussion Symptoms Questionnaire. The bimanual cost was present at both testing sessions in patients and healthy controls. Although overall reaction times were slower in concussed patients during session 1, these had improved by session 2, as did the symptom scores. These findings suggest that the pathogenesis of mild traumatic brain injury involves intrahemispheric cortical networks rather than impaired interhemispheric communication via the CC.
胼胝体（CC）被认为在创伤性脑损伤中特别脆弱。双手成本（与单手相比，双手反应时间较慢）是 CC 功能的敏感指标。为了确定 CC 功能障碍是否是轻度创伤性脑损伤的一个重要特征，研究了 10 名最近脑震荡的患者和 10 名健康参与者的单手和双手反应时间。反应时间在脑震荡后 1 周内进行研究，并在 1 个月后再次进行研究。使用 Rivermead 脑震荡后症状问卷评估脑震荡症状。在患者和健康对照组的两次测试中均存在双手成本。尽管在第 1 次测试中，脑震荡患者的整体反应时间较慢，但在第 2 次测试中，反应时间有所改善，症状评分也是如此。这些发现表明，轻度创伤性脑损伤的发病机制涉及半球内皮质网络，而不是通过 CC 受损的半球间通讯。
