Zoonoses and Emerging Infections Group, Clinical Virology, Department of Pathobiology, University of Veterinary Medicine, Vienna, Veterinärplatz 1, 1210 Vienna, Austria.
Vet J. 2011 Mar;187(3):399-401. doi: 10.1016/j.tvjl.2009.12.029. Epub 2010 Jan 25.
A widespread, severe outbreak of canine distemper encephalitis was observed in wildlife in Southern Bavaria in the spring and summer of 2008. The haemagglutinin (HA) genes of six representative canine distemper virus (CDV) samples originating from five red foxes and one badger during this outbreak had a Y549H amino acid substitution in the HA protein compared to sequences from two captive domesticated ferrets which succumbed to CDV in the same area 2 years earlier. As this specific substitution at the receptor-binding site has been hypothesised to contribute to the emergence of CDV and its spread to novel hosts, the outbreak in wildlife in Southern Bavaria might, directly or indirectly, be associated with a Y549H amino acid exchange.
2008 年春夏季，巴伐利亚南部野生动物中爆发了一场广泛而严重的犬瘟热脑炎疫情。在这次疫情中，来自五只红狐和一只獾的六份代表性犬瘟热病毒（CDV）样本的血凝素（HA）基因与两年前在同一地区死于 CDV 的两只圈养驯化雪貂的序列相比，HA 蛋白中的 Y549H 氨基酸发生了取代。由于在受体结合部位的这种特定取代被假设有助于 CDV 的出现及其传播到新宿主，因此巴伐利亚南部野生动物中的疫情可能直接或间接地与 Y549H 氨基酸交换有关。
