2012年至2013年在中国东北地区接种疫苗的食肉动物中检测到血凝素蛋白发生两个氨基酸替换的犬瘟热病毒株的出现。
Emergence of canine distemper virus strains with two amino acid substitutions in the haemagglutinin protein, detected from vaccinated carnivores in North-Eastern China in 2012-2013.
作者信息
Zhao Jianjun, Zhang Hailing, Bai Xue, Martella Vito, Hu Bo, Sun Yangang, Zhu Chunsheng, Zhang Lei, Liu Hao, Xu Shujuan, Shao Xiqun, Wu Wei, Yan Xijun
机构信息
Division of Infectious Diseases, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China; State Key Laboratory for Molecular Biology, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China.
Division of Infectious Diseases, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China.
出版信息
Vet J. 2014 Apr;200(1):191-4. doi: 10.1016/j.tvjl.2014.01.028. Epub 2014 Feb 11.
A total of 16 strains of canine distemper virus (CDV) were detected from vaccinated minks, foxes, and raccoon dogs in four provinces in North-Eastern China between the end of 2011 and 2013. Upon sequence analysis of the haemagglutinin gene and comparison with wild-type CDV from different species in the same geographical areas, two non-synonymous single nucleotide polymorphisms were identified in 10 CDV strains, which led to amino acid changes at positions 542 (isoleucine to asparagine) and 549 (tyrosine to histidine) of the haemagglutinin protein coding sequence. The change at residue 542 generated a potentially novel N-glycosylation site. Masking of antigenic epitopes by sugar moieties might represent a mechanism for evasion of virus neutralising antibodies and reduced protection by vaccination.
2011年末至2013年间，在中国东北地区四个省份的接种疫苗的水貂、狐狸和貉中，共检测到16株犬瘟热病毒（CDV）。对血凝素基因进行序列分析，并与同一地理区域不同物种的野生型CDV进行比较后，在10株CDV毒株中鉴定出两个非同义单核苷酸多态性，这导致血凝素蛋白编码序列第542位（异亮氨酸变为天冬酰胺）和第549位（酪氨酸变为组氨酸）的氨基酸发生变化。第542位残基的变化产生了一个潜在的新N-糖基化位点。糖部分对抗抗原表位的掩盖可能是病毒逃避中和抗体以及疫苗保护作用降低的一种机制。
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