活检证实的巨细胞动脉炎患者的癌症风险。
Risk of cancer in patients with biopsy-proven giant cell arteritis.
机构信息
Rheumatology Unit, Queen Elizabeth Hospital, Woodville, Australia.
出版信息
Rheumatology (Oxford). 2010 Apr;49(4):756-9. doi: 10.1093/rheumatology/kep409. Epub 2010 Jan 20.
OBJECTIVE
Results of previous studies investigating the association between GCA and malignancy are conflicting. We performed a study of the risk of cancer in patients with biopsy-proven GCA.
METHODS
Patients with biopsy-proven GCA were identified from pathology reports of temporal artery biopsies from the major pathology laboratories in South Australia (SA). All subjects with biopsy-proven GCA were linked to the SA Cancer Registry to identify cases of cancer until 31 December 2006. Standardized incidence ratios (SIRs) for cancer were determined using the age- and gender-specific rates for SA.
RESULTS
There were 226 cases of biopsy-proven GCA (163 females and 63 males). Thirty-one cases were diagnosed with cancer, following the diagnosis of biopsy-proven GCA. There was no increased risk of cancer among those with biopsy-proven GCA, following the diagnosis of GCA compared with the general population (SIR 1.2; 95% CI 0.8, 1.6).
CONCLUSION
This cohort study did not demonstrate any increased risk for malignancy in subjects with biopsy-proven GCA.
目的
先前研究调查巨细胞动脉炎（GCA）与恶性肿瘤之间的关系的结果相互矛盾。我们对经活检证实的 GCA 患者的癌症风险进行了研究。
方法
从南澳大利亚（SA）主要病理实验室的颞动脉活检病理报告中确定了经活检证实的 GCA 患者。所有经活检证实的 GCA 患者均与 SA 癌症登记处相关联，以确定截至 2006 年 12 月 31 日的癌症病例。使用 SA 的年龄和性别特异性率确定癌症的标准化发病比（SIR）。
结果
有 226 例经活检证实的 GCA（163 名女性和 63 名男性）。在诊断为经活检证实的 GCA 后，有 31 例被诊断患有癌症。与普通人群相比，在诊断为 GCA 后，GCA 患者的癌症风险没有增加（SIR 1.2；95%CI 0.8，1.6）。
结论
本队列研究并未表明经活检证实的 GCA 患者的恶性肿瘤风险增加。
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