Kong S K, Xu J, Becker A B, Kepron W, Stephens N L
Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
Am Rev Respir Dis. 1991 Apr;143(4 Pt 1):783-6. doi: 10.1164/ajrccm/143.4_Pt_1.783.
Tracheal smooth muscles from adult dogs 17 to 20 months of age sensitized with ragweed pollen demonstrated a Schultz-Dale phenomenon in response to specific antigen challenge. Seventy percent of the sensitized tracheal smooth muscles developed a Schultz-Dale reaction that consisted only of a phasic response, and the remaining 30% developed a Schultz-Dale reaction that consisted of a phasic component followed by a discrete tonic component. All the Schultz-Dale reactions were mediated only by histamine. The triggering of presynaptic acetylcholine release by histamine during the Schultz-Dale reaction from tracheal smooth muscles of ragweed-pollen-sensitized puppies 6 to 8 months of age was not detected in sensitized adult dogs. Hyperresponsiveness to acetylcholine was detected in tissues from sensitized puppies but not from sensitized adult dogs. Maximal active tension obtained from the sensitized adult canine trachealis during the Schultz-Dale reaction was lower than that obtained from trachealis from sensitized puppies. Dose-response studies showed that sensitized tissues used in the present studies were hyperresponsive to histamine when compared with their nonsensitized control littermates. These results suggest that the nature of the Schultz-Dale response and the identity of the transmitters is age-dependent.
用豚草花粉致敏的17至20月龄成年犬的气管平滑肌，在受到特异性抗原攻击时表现出舒尔茨 - 戴尔现象。70%的致敏气管平滑肌产生仅由相性反应组成的舒尔茨 - 戴尔反应，其余30%产生由相性成分后接离散强直性成分组成的舒尔茨 - 戴尔反应。所有舒尔茨 - 戴尔反应仅由组胺介导。在6至8月龄豚草花粉致敏幼犬的气管平滑肌舒尔茨 - 戴尔反应期间，组胺触发突触前乙酰胆碱释放的现象在致敏成年犬中未被检测到。在致敏幼犬的组织中检测到对乙酰胆碱的高反应性，但在致敏成年犬中未检测到。在舒尔茨 - 戴尔反应期间，致敏成年犬气管平滑肌获得的最大主动张力低于致敏幼犬气管平滑肌获得的最大主动张力。剂量反应研究表明，与未致敏的同窝对照相比，本研究中使用的致敏组织对组胺反应性过高。这些结果表明，舒尔茨 - 戴尔反应的性质和递质的特性是年龄依赖性的。
