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离体肺条和单个开放气管环:用于表征豚鼠外周和中央气道舒尔茨-戴尔过敏反应性收缩的便捷组合。

The isolated lung strip and single open tracheal ring: a convenient combination for characterizing Schultz Dale anaphylactic contractions in the peripheral and central airways of the guinea-pig.

作者信息

Lulich K M, Papadimitriou J M, Paterson J W

出版信息

Clin Exp Pharmacol Physiol. 1979 Nov-Dec;6(6):625-9. doi: 10.1111/j.1440-1681.1979.tb00046.x.

DOI:10.1111/j.1440-1681.1979.tb00046.x
PMID:519910
Abstract
  1. The use of the isolated lung strip and single open tracheal ring for studying Schultz Dale anaphylactic contractions in both the peripheral and central airways is described. 2. This method is particularly relevant to studies of anaphylaxis because many preparations may be obtained from a single sensitized animal. 3. Isolated preparations from control guinea-pigs did not respond to ovalbumin, whereas the lung strip and trachea taken from guinea-pigs sensitized to ovalbumin, contracted markedly to that antigen. 4. The peripheral and central airways from sensitized animals responded in the same way to antigen challenge.
摘要
  1. 描述了使用离体肺条和单个开放气管环来研究外周和中央气道中的舒尔茨-戴尔过敏收缩反应。2. 这种方法对于过敏反应的研究特别相关,因为可以从一只致敏动物获得许多标本。3. 来自对照豚鼠的离体标本对卵清蛋白无反应,而从对卵清蛋白致敏的豚鼠获取的肺条和气管对该抗原产生明显收缩。4. 致敏动物的外周和中央气道对抗原刺激的反应方式相同。

相似文献

1
The isolated lung strip and single open tracheal ring: a convenient combination for characterizing Schultz Dale anaphylactic contractions in the peripheral and central airways of the guinea-pig.离体肺条和单个开放气管环:用于表征豚鼠外周和中央气道舒尔茨-戴尔过敏反应性收缩的便捷组合。
Clin Exp Pharmacol Physiol. 1979 Nov-Dec;6(6):625-9. doi: 10.1111/j.1440-1681.1979.tb00046.x.
2
The cat lung strip as an in vitro preparation of peripheral airways: a comparison of beta-adrenoceptor agonists, autacoids and anaphylactic challenge on the lung strip and trachea.猫肺条作为外周气道的体外制备物:β-肾上腺素能受体激动剂、自分泌物质及过敏反应对肺条和气管作用的比较
Br J Pharmacol. 1976 Sep;58(1):71-9. doi: 10.1111/j.1476-5381.1976.tb07694.x.
3
Anaphylaxis in guinea-pig peripheral airways in vitro.豚鼠外周气道体外过敏反应
Eur J Pharmacol. 1979 Feb 15;54(1-2):69-78. doi: 10.1016/0014-2999(79)90409-6.
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Beta-endorphin modulates anaphylactic contractions of tracheae isolated from actively sensitized guinea pigs.β-内啡肽可调节从主动致敏豚鼠分离出的气管的过敏收缩。
Agents Actions. 1990 Apr;30(1-2):89-91. doi: 10.1007/BF01969006.
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Epithelium-dependent potentiation of anaphylactic contractions by beta-endorphin in tracheae isolated from actively sensitized guinea-pigs.在从主动致敏豚鼠分离的气管中,β-内啡肽对过敏性收缩的上皮依赖性增强作用。
Br J Pharmacol. 1991 Jun;103(2):1470-4. doi: 10.1111/j.1476-5381.1991.tb09813.x.
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Dual modes of action for disodium cromoglycate in inhibition of antigen-induced contractions of guinea-pig isolated airways smooth muscle.色甘酸钠抑制豚鼠离体气道平滑肌抗原诱导收缩的双重作用模式。
Clin Exp Pharmacol Physiol. 1983 Sep-Oct;10(5):595-603. doi: 10.1111/j.1440-1681.1983.tb00228.x.
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Parainfluenza 3 infection blocks the ability of a beta adrenergic receptor agonist to inhibit antigen-induced contraction of guinea pig isolated airway smooth muscle.副流感病毒3型感染会阻断β肾上腺素能受体激动剂抑制抗原诱导的豚鼠离体气道平滑肌收缩的能力。
J Clin Invest. 1981 Feb;67(2):376-84. doi: 10.1172/JCI110045.
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Differentiation of functional adrenoceptors in human and guinea pig airways.人和豚鼠气道中功能性肾上腺素能受体的分化
Eur J Respir Dis Suppl. 1984;135:16-33.
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Decreased Schultz-Dale reaction in airways from sensitized guinea pigs treated with threshold concentrations of egg albumin in vivo.体内用阈浓度卵清蛋白处理的致敏豚鼠气道中舒尔茨-戴尔反应降低。
Acta Pharmacol Toxicol (Copenh). 1982 Jan;50(1):35-40. doi: 10.1111/j.1600-0773.1982.tb00937.x.
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Changes in Schultz-Dale reaction in sensitized canine tracheal smooth muscle.致敏犬气管平滑肌舒尔茨-戴尔反应的变化。
Am Rev Respir Dis. 1991 Apr;143(4 Pt 1):783-6. doi: 10.1164/ajrccm/143.4_Pt_1.783.

引用本文的文献

1
Differential regulation of the release of tumor necrosis factor-alpha and of eicosanoids by mast cells in rat airways after antigen challenge.抗原激发后大鼠气道中肥大细胞对肿瘤坏死因子-α和类花生酸释放的差异调节。
Mediators Inflamm. 2003 Aug;12(4):237-46. doi: 10.1080/09629350310001599684.
2
Bronchodilator-mediated relaxation of normal and ovalbumin-sensitized guinea-pig airways: lack of correlation with lung adenylate cyclase activation.支气管扩张剂介导的正常和卵清蛋白致敏豚鼠气道舒张:与肺腺苷酸环化酶激活缺乏相关性。
Br J Pharmacol. 1984 Nov;83(3):645-55. doi: 10.1111/j.1476-5381.1984.tb16218.x.
3
Pharmacological modulation of responses of guinea-pig airways contracted with antigen and calcium ionophore A23187.
豚鼠气道对抗原和钙离子载体A23187收缩反应的药理学调节
Br J Pharmacol. 1985 Jun;85(2):411-20. doi: 10.1111/j.1476-5381.1985.tb08876.x.
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Pharmacological modulation of responses of guinea-pig airways contracted with arachidonic acid.对用花生四烯酸收缩的豚鼠气道反应的药理学调节。
Br J Pharmacol. 1985 Jun;85(2):421-5. doi: 10.1111/j.1476-5381.1985.tb08877.x.