离体肺条和单个开放气管环：用于表征豚鼠外周和中央气道舒尔茨-戴尔过敏反应性收缩的便捷组合。

The isolated lung strip and single open tracheal ring: a convenient combination for characterizing Schultz Dale anaphylactic contractions in the peripheral and central airways of the guinea-pig.

Lulich K M, Papadimitriou J M, Paterson J W

Clin Exp Pharmacol Physiol. 1979 Nov-Dec;6(6):625-9. doi: 10.1111/j.1440-1681.1979.tb00046.x.

Abstract

The use of the isolated lung strip and single open tracheal ring for studying Schultz Dale anaphylactic contractions in both the peripheral and central airways is described. 2. This method is particularly relevant to studies of anaphylaxis because many preparations may be obtained from a single sensitized animal. 3. Isolated preparations from control guinea-pigs did not respond to ovalbumin, whereas the lung strip and trachea taken from guinea-pigs sensitized to ovalbumin, contracted markedly to that antigen. 4. The peripheral and central airways from sensitized animals responded in the same way to antigen challenge.

摘要

描述了使用离体肺条和单个开放气管环来研究外周和中央气道中的舒尔茨-戴尔过敏收缩反应。2. 这种方法对于过敏反应的研究特别相关，因为可以从一只致敏动物获得许多标本。3. 来自对照豚鼠的离体标本对卵清蛋白无反应，而从对卵清蛋白致敏的豚鼠获取的肺条和气管对该抗原产生明显收缩。4. 致敏动物的外周和中央气道对抗原刺激的反应方式相同。