Department of Conservative of Dentistry and Periodontology, School of Dental Medicine, Christian-Albrechts-Universität, Kiel, Germany.
Caries Res. 2010;44(1):47-54. doi: 10.1159/000275917. Epub 2010 Jan 16.
The infiltration of caries lesions with low-viscosity light-curing resins (infiltrants) has been shown to inhibit further demineralization in vitro. The aim of the present study was to assess the efficacy of resin infiltration in preventing lesion progression in situ. In each of 104 bovine enamel specimens, 2 artificial enamel caries lesions were created. The specimens were randomly allocated to 2 groups: in the test group, 1 of the lesions was etched for 5 s (37% H(3)PO(4)) and subsequently infiltrated twice with a preproduct infiltrant, each time for 60 s. As a positive control, 1 lesion was superficially sealed with a fissure sealant. The second lesion in each specimen served as an untreated control. The specimens were inserted into intraoral appliances and worn by 11 volunteers in the mandibular buccal sulcus for 100 days. Plaque accumulation was promoted by a mesh, and the appliances were stored in 10% sucrose solution (2 x 30 min/day). The specimens were analyzed using transversal microradiography and wavelength-independent microradiography. The specimens of 2 participants were excluded from analysis. The baseline integrated mineral losses (transversal microradiography values; mean +/- SD: 2474 +/- 549 vol% x mum) and lesion depths (98 +/- 20 mum) did not differ significantly between the various groups (p > 0.05; paired t test). After the in situ phase, the infiltrated and positive control lesions showed significantly less progression compared to the untreated controls (p < 0.05). It can be concluded that resin infiltration is efficacious in preventing further demineralization of artificial enamel caries lesions under cariogenic conditions in situ.
牙本质龋的渗透用低粘度的光固化树脂（渗透剂）已被证明可以抑制体外进一步脱矿。本研究的目的是评估树脂渗透在防止原位病变进展中的疗效。在 104 个牛牙釉质标本中，每个标本均创建了 2 个人工牙釉质龋损。将标本随机分为 2 组：在实验组中，1 个病变用 37%的 H3PO4 蚀刻 5 s，然后用预聚物渗透剂渗透两次，每次渗透 60 s。作为阳性对照，1 个病变用窝沟封闭剂进行表面封闭。每个标本中的第二个病变作为未经处理的对照。标本插入口腔内装置中，由 11 名志愿者在下颌颊沟中佩戴 100 天。通过网格促进菌斑积聚，每天将器械储存在 10%蔗糖溶液中（2 x 30 min）。使用横向显微放射摄影术和波长独立的显微放射摄影术分析标本。2 名参与者的标本被排除在分析之外。基线整合矿物质损失（横向显微放射摄影术值；平均值 +/- SD：2474 +/- 549 vol% x mum）和病变深度（98 +/- 20 mum）在各组之间无显着差异（p > 0.05;配对 t 检验）。在原位阶段后，与未经处理的对照组相比，渗透和阳性对照组的病变进展明显较少（p < 0.05）。可以得出结论，在致龋条件下，树脂渗透可有效防止人工牙釉质龋病的进一步脱矿。
