Sir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, New Zealand.
Paediatric Dentistry, UWA Dental School, The University of Western Australia, Perth, Australia.
Clin Exp Dent Res. 2024 Apr;10(2):e876. doi: 10.1002/cre2.876.
This study evaluated the remineralization potential of calcium sodium phosphosilicate and functionalized tri-calcium phosphate (f-TCP) dentifrices in deeper incipient carious lesions (ICLs).
Artificial ICLs were created by placing premolars into demineralizing solutions. Teeth were randomly assigned into four groups: calcium sodium phosphosilicate (Group 1), f-TCP (Group 2), 1450 ppm fluoride (Group 3), and distilled water (Group 4), which were subjected to 10-day pH cycling. Mineral density (MD) was assessed using microcomputed tomography (Micro-CT), while hardness (H) and elastic modulus (EM) were assessed using nanomechanical testing.
MD % gain was higher in Groups 1-3 than in Group 4. In addition, Groups 1 and 2 exhibited significantly higher MD % gain than Group 3. Also, Groups 1-3 showed significantly higher EM and H values than Group 4 in the outer enamel area; yet, Groups 1 and 2 displayed significantly higher EM and H values than Groups 3 and 4 in the inner enamel.
The MD, EM, and H of ICLs significantly increased with the addition of calcium sodium phosphosilicate or f-TCP to fluoridated dentifrices compared to standard fluoride dentifrices. The added active ingredients remineralized the deeper parts of the ICLs, while remineralization at the lesion surface was similar between tested dentifrices.
本研究评估了硅钙钠磷酸钙和功能化三钙磷酸盐（f-TCP）牙膏在较深的初始龋损（ICL）中的再矿化潜力。
通过将前磨牙放入脱矿溶液中创建人工 ICL。牙齿被随机分配到四组：硅钙钠磷酸钙（第 1 组）、f-TCP（第 2 组）、1450ppm 氟化物（第 3 组）和蒸馏水（第 4 组），然后进行 10 天 pH 循环。使用微计算机断层扫描（Micro-CT）评估矿物质密度（MD），使用纳米力学测试评估硬度（H）和弹性模量（EM）。
第 1-3 组的 MD%增益高于第 4 组。此外，第 1 组和第 2 组的 MD%增益明显高于第 3 组。此外，第 1-3 组在外釉质区的 EM 和 H 值明显高于第 4 组；然而，第 1 组和第 2 组在釉内层的 EM 和 H 值明显高于第 3 组和第 4 组。
与标准氟化物牙膏相比，在含氟牙膏中添加硅钙钠磷酸钙或 f-TCP 可显著提高 ICL 的 MD、EM 和 H。添加的活性成分使 ICL 的较深部位再矿化，而测试牙膏在病变表面的再矿化相似。
