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血清γ-谷氨酰转移酶与美国成年人慢性肾脏病的关系。

Association between serum gamma-glutamyltransferase and chronic kidney disease among US adults.

机构信息

Department of Community Medicine, West Virginia University School of Medicine, Morgantown, USA.

出版信息

Kidney Blood Press Res. 2010;33(1):1-6. doi: 10.1159/000274463. Epub 2010 Jan 13.

Abstract

BACKGROUND/AIM: Serum gamma-glutamyltransferase (GGT), a biomarker of oxidative stress, is associated with an increased risk of diabetes and hypertension. However, it is not known whether higher serum GGT is independently associated with chronic kidney disease (CKD). Therefore, we examined the association between serum GGT levels and CKD in a representative sample of US adults.

METHODS

We conducted a cross-sectional study of 9,516 National Health and Nutrition Examination Survey 1999-2002 participants >or=18 years of age (52.40% women). Serum GGT was categorized into quartiles for the analysis. CKD (n = 622) was defined as an estimated glomerular filtration rate of <60 ml/min/1.73 m(2).

RESULTS AND CONCLUSION

Higher serum GGT levels were not associated with CKD after adjusting for age, sex, race/ethnicity, education levels, smoking, alcohol intake, body mass index (BMI), diabetes, hypertension and serum cholesterol. Compared to quartile 1 of GGT, the odds ratio (95% confidence interval) of CKD associated with quartile 4 was 1.02 (0.81-1.28); p trend = 0.377. Subgroup analyses that examined the relation between GGT and CKD by gender, alcohol intake, and BMI categories also showed a consistent null association. In summary, there was no association between increasing levels of serum GGT and CKD in a sample of US adults.

摘要

背景/目的:血清γ-谷氨酰转移酶(GGT)是一种氧化应激的生物标志物,与糖尿病和高血压风险增加有关。然而,目前尚不清楚血清 GGT 升高是否与慢性肾脏病(CKD)独立相关。因此,我们在一个具有代表性的美国成年人样本中检查了血清 GGT 水平与 CKD 之间的关系。

方法

我们对 1999-2002 年参加国家健康和营养调查的 9516 名年龄>或=18 岁的成年人(52.40%为女性)进行了一项横断面研究。血清 GGT 按四分位数进行分类。CKD(n = 622)定义为估算肾小球滤过率<60 ml/min/1.73 m(2)。

结果与结论

在调整年龄、性别、种族/民族、教育程度、吸烟、饮酒量、体重指数(BMI)、糖尿病、高血压和血清胆固醇后,较高的血清 GGT 水平与 CKD 无关。与 GGT 四分位 1 相比,GGT 四分位 4 与 CKD 的比值比(95%置信区间)为 1.02(0.81-1.28);p 趋势=0.377。按性别、饮酒量和 BMI 类别对 GGT 与 CKD 之间的关系进行的亚组分析也显示出一致的零关联。总之,在一个美国成年人样本中,血清 GGT 水平升高与 CKD 之间没有关联。

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