Chen Tao, Ren Yan, Gao Yun, Tian Haoming
Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu 610041, China.
Dis Markers. 2017;2017:9765259. doi: 10.1155/2017/9765259. Epub 2017 Jun 4.
The present study investigated the effects of GGT and SF on the risk of CKD. 1024 participants (436 men and 588 women) were divided into three groups according to GGT and SF levels: group 1 (both GGT and SF not in the fourth quartile), group 2 (only GGT or SF in the fourth quartile), and group 3 (both GGT and SF in the fourth quartile). The risks of CKD in different levels of GGT and SF and in groups 2-3 compared with group 1 were analyzed by multiple logistic regression. GGT or SF in the highest quartile was associated with increased risk of CKD. Such associations attenuated after adjustment for confounding factors. The incidences of CKD, especially albuminuria, increased across the three groups. Correspondingly, malondialdehyde (MDA) levels gradually increased from group 1 to group 3. The risks of CKD were higher in groups 2 and 3 than that in group 1. In group 3, the increased rate was independent of age, BMI, alcohol drinking, diabetes mellitus, hypertension, hypertriglyceridemia, and metabolic syndrome (odds ratios from 1.887 to 2.293, < 0.05). In summary, this study suggested that GGT and SF synergistically influence the rate of CKD.
本研究调查了γ-谷氨酰转移酶（GGT）和铁蛋白（SF）对慢性肾脏病（CKD）风险的影响。1024名参与者（436名男性和588名女性）根据GGT和SF水平分为三组：第1组（GGT和SF均不在第四四分位数）、第2组（仅GGT或SF在第四四分位数）和第3组（GGT和SF均在第四四分位数）。通过多因素逻辑回归分析不同水平的GGT和SF以及第2 - 3组与第1组相比的CKD风险。GGT或SF处于最高四分位数与CKD风险增加相关。在对混杂因素进行调整后，这种关联减弱。三组中CKD的发生率，尤其是蛋白尿的发生率均有所增加。相应地，丙二醛（MDA）水平从第1组到第3组逐渐升高。第2组和第3组的CKD风险高于第1组。在第3组中，增加率独立于年龄、体重指数、饮酒、糖尿病、高血压、高甘油三酯血症和代谢综合征（比值比为1.887至2.293，<0.05）。总之，本研究表明GGT和SF协同影响CKD的发生率。
