尿褪黑素与年轻女性新发高血压的风险。
Urinary melatonin and risk of incident hypertension among young women.
机构信息
Channing Laboratory, Department of Medicine, 181 Longwood Avenue, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
出版信息
J Hypertens. 2010 Mar;28(3):446-51. doi: 10.1097/HJH.0b013e3283340c16.
OBJECTIVE
Administered in supraphysiologic doses, the hormone melatonin may reduce blood pressure, particularly nocturnal blood pressure. However, whether lower physiologic levels of melatonin are an independent risk factor for the development of hypertension has never been reported.
METHODS
We examined the association between first morning urine melatonin levels and the risk of developing hypertension among 554 young women without baseline hypertension who were followed for 8 years. Cox proportional hazards models were adjusted for age, BMI, physical activity, alcohol intake, smoking status, urinary creatinine, and family history of hypertension.
RESULTS
During 8 years of follow-up, a total of 125 women developed hypertension. The relative risk for incident hypertension among women in the highest quartile of urinary melatonin (>27.0 ng/mg creatinine) as compared with the lowest quartile (<10.1 ng/mg creatinine) was 0.49 (95% confidence interval 0.28-0.85, P < 0.001).
CONCLUSION
First morning melatonin levels are independently and inversely associated with incident hypertension; low melatonin production may be a pathophysiologic factor in the development of hypertension.
目的
在超生理剂量下，激素褪黑素可能会降低血压，尤其是夜间血压。然而，褪黑素的较低生理水平是否是高血压发展的独立危险因素尚未有报道。
方法
我们研究了 554 名无基线高血压的年轻女性在 8 年随访期间的晨尿褪黑素水平与高血压发病风险之间的关联。Cox 比例风险模型调整了年龄、BMI、体力活动、饮酒量、吸烟状况、尿肌酐和高血压家族史。
结果
在 8 年的随访期间，共有 125 名女性患上了高血压。与最低四分位数（<10.1ng/mg 肌酐）相比，尿褪黑素最高四分位数（>27.0ng/mg 肌酐）的女性发生高血压的相对风险为 0.49（95%置信区间 0.28-0.85，P<0.001）。
结论
晨尿褪黑素水平与新发高血压独立且呈负相关；褪黑素生成减少可能是高血压发展的病理生理因素。
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