University of Pittsburgh, Drug Discovery Institute, Pittsburgh, PA 15261, USA.
Org Biomol Chem. 2010 Feb 7;8(3):529-32. doi: 10.1039/b918214d. Epub 2009 Nov 26.
The newly discovered natural product bacillamide C and several derivatives were convergently synthesized for the first time and in only three steps. The key transformation constitutes a thiazole Ugi multicomponent reaction. These compounds will serve to elucidate chemical biology and SAR of this potent anti-algae natural product and shows the synthetic pathway to related natural products.
新发现的天然产物 bacillamide C 及其几种衍生物首次通过仅三步的方法进行了汇聚合成。关键转化构成了噻唑 Ugi 多组分反应。这些化合物将用于阐明这种强效抗藻类天然产物的化学生物学和 SAR，并展示了相关天然产物的合成途径。
