Zhang Yuqi, Islam Md Amirul, McAlpine Shelli R
School of Chemistry, The University of New South Wales , Gate 2 High Street, Sydney 2052, Australia.
Org Lett. 2015 Nov 6;17(21):5149-51. doi: 10.1021/acs.orglett.5b02574. Epub 2015 Oct 15.
The first total synthesis of marthiapeptide A is reported. Two synthetic procedures are described: the first, which was unsuccessful, attempts to close the ring at position I, and the second, which was successful, closes the ring at position II. It appears that the first route was unsuccessful because it required cyclization next to the rigid thiazole moiety, whereas the second route closed next to the more flexible thiazoline ring.
报道了玛西亚肽A的首次全合成。描述了两种合成方法：第一种方法未成功，试图在位置I处闭环；第二种方法成功，在位置II处闭环。第一种路线未成功似乎是因为它需要在刚性噻唑部分旁边进行环化，而第二种路线是在更灵活的噻唑啉环旁边闭环。
