Rahn K H
Department of Medicine D, Universität Münster, FRG.
Am J Hypertens. 1991 Jan;4(1 Pt 2):38S-41S. doi: 10.1093/ajh/4.1.38s.
The angiotensin converting enzyme (ACE) inhibitors delapril and enalapril were compared in a double-blind, randomized, parallel study. The population included 142 patients with essential hypertension who were treated with delapril and 140 treated with enalapril. At the end of a 2 week initial placebo period, the diastolic blood pressure of these patients ranged from 95 to 115 mm Hg in the sitting position. After this placebo period, randomization took place. Patients in the delapril group received 15 mg of the drug twice daily. Treatment with enalapril was started with a daily dose of 10 mg. If the diastolic blood pressure did not fall to less than or equal to 90 mm Hg or at least by 15 mm Hg after 2 weeks of treatment, the doses of the ACE inhibitors were doubled. After another 2 weeks, 25 mg hydrochlorothiazide daily was added if the target level of diastolic blood pressure was not reached. Both drugs caused a similar decrease of systolic and diastolic blood pressure. The antihypertensive effect of both ACE inhibitors was increased by the addition of the diuretic. The frequency and severity of side effects were similar in the two groups of patients. It is concluded from this study that delapril and enalapril do not differ in antihypertensive efficacy nor in safety.
在一项双盲、随机、平行研究中，对血管紧张素转换酶（ACE）抑制剂地拉普利和依那普利进行了比较。研究对象包括142例接受地拉普利治疗的原发性高血压患者和140例接受依那普利治疗的患者。在为期2周的初始安慰剂期结束时，这些患者坐位时的舒张压在95至115毫米汞柱之间。在这个安慰剂期结束后进行随机分组。地拉普利组患者每日两次服用15毫克该药物。依那普利治疗从每日剂量10毫克开始。如果治疗2周后舒张压未降至小于或等于90毫米汞柱或至少下降15毫米汞柱，则将ACE抑制剂的剂量加倍。再过2周后，如果未达到舒张压目标水平，则每日加用25毫克氢氯噻嗪。两种药物引起的收缩压和舒张压下降相似。加用利尿剂后，两种ACE抑制剂的降压效果均增强。两组患者副作用的频率和严重程度相似。从这项研究得出的结论是，地拉普利和依那普利在降压疗效和安全性方面没有差异。
